Immunohistochemistry features of SMZL and other small B-cell lymphomas
| . | SMZL . | LPL . | SDRPL . | HCL-v . | HCL . | EMZL/ NMZL . | CLL . | MCL . | FL . |
|---|---|---|---|---|---|---|---|---|---|
| CD20 | + | + | + | + | + | + | −/+ | + | + |
| CD79a | + | + | + | + | + | + | + | + | + |
| CD5 | −/+ | −/+ | −/+ | – | – | −/+ | + | + | – |
| CD21 | −/+ | – | – | – | – | – | – | – | – |
| CD23 | −/+ | −/+ | – | – | – | −/+ | + | – | −/+ |
| BCL1 | – | – | – | −/+ | + | – | – | + | – |
| DBA44 | +/− | – | + | + | + | – | −/+ | – | – |
| Annexin A1 | – | – | – | – | + | – | – | – | – |
| CD103 | – | – | – | +/− | + | – | – | – | – |
| CD123 | – | – | – | – | + | – | – | – | – |
| IRTA1 | – | – | – | – | – | +/− | – | – | – |
| IgM | + | + | + | + | + | + | + | + | + |
| IgD | +/− | – | −/+ | + | + | −/+ | + | + | + |
| CD10 | – | –* | – | – | – | – | – | –* | +/− |
| BCL6 | – | – | – | – | – | −/+ | – | −/+ | + |
| CD43 | −/+ | – | – | – | – | −/+ | + | + | – |
| SOX11 | – | – | – | – | – | – | – | + | – |
| LEF1 | – | – | – | – | – | – | + | −/+ | – |
| . | SMZL . | LPL . | SDRPL . | HCL-v . | HCL . | EMZL/ NMZL . | CLL . | MCL . | FL . |
|---|---|---|---|---|---|---|---|---|---|
| CD20 | + | + | + | + | + | + | −/+ | + | + |
| CD79a | + | + | + | + | + | + | + | + | + |
| CD5 | −/+ | −/+ | −/+ | – | – | −/+ | + | + | – |
| CD21 | −/+ | – | – | – | – | – | – | – | – |
| CD23 | −/+ | −/+ | – | – | – | −/+ | + | – | −/+ |
| BCL1 | – | – | – | −/+ | + | – | – | + | – |
| DBA44 | +/− | – | + | + | + | – | −/+ | – | – |
| Annexin A1 | – | – | – | – | + | – | – | – | – |
| CD103 | – | – | – | +/− | + | – | – | – | – |
| CD123 | – | – | – | – | + | – | – | – | – |
| IRTA1 | – | – | – | – | – | +/− | – | – | – |
| IgM | + | + | + | + | + | + | + | + | + |
| IgD | +/− | – | −/+ | + | + | −/+ | + | + | + |
| CD10 | – | –* | – | – | – | – | – | –* | +/− |
| BCL6 | – | – | – | – | – | −/+ | – | −/+ | + |
| CD43 | −/+ | – | – | – | – | −/+ | + | + | – |
| SOX11 | – | – | – | – | – | – | – | + | – |
| LEF1 | – | – | – | – | – | – | + | −/+ | – |
–, <25% of cases; –/+, 25%-50% of cases; +/–, 50%-75% of cases; +, >75% of cases.
FL, follicular lymphoma; NMZL, nodal marginal zone lymphoma; SDRPL, splenic diffuse red pulp lymphoma.
Sporadic cases reported.