Deregulated genes in patient-paired MRD vs diagnostic clonal PCs and their prognostic value according to mRNA expression levels in PCs from newly diagnosed patients treated according to TT3A (training set) and TT3B (validation set)
| Genes . | Expression in MRD vs diagnostic clonal PCs . | Expression in TT3 patients . | TT3A (training set) . | TT3B (validation set) . | ||
|---|---|---|---|---|---|---|
| Median (years) . | P value . | Median (years) . | P value . | |||
| Cancer related | ||||||
| FERMT3 | (↑) | >9.8 | NR | .03 | NR | .03 |
| ≤9.8 | NR | NR | ||||
| TSPO | (↑) | >11.55 | 7 | .06 | 3 | .0002 |
| ≤11.55 | NR | NR | ||||
| ALOX5 | (↑) | >12.39 | NR | .07 | NR | .11 |
| ≤12.39 | NR | NR | ||||
| NCF4 | (↑) | >10.58 | NR | .09 | 7 | .2 |
| ≤10.58 | NR | NR | ||||
| FLNA | (↑) | >10.56 | 7 | .0002 | 6 | .003 |
| ≤10.56 | NR | NR | ||||
| PREX1 | (↑) | >5.33 | NR | .02 | NR | .79 |
| ≤5.33 | 7 | NR | ||||
| PYCARD | (↑) | >9.37 | 9 | .001 | NR | .35 |
| ≤9.37 | NR | NR | ||||
| MYO1G | (↑) | >4.66 | NR | .01 | NR | .09 |
| ≤4.66 | 7 | NR | ||||
| SERPINI1 | (↓) | >9.85 | NR | .11 | NR | .47 |
| ≤9.85 | NR | NR | ||||
| DUSP11 | (↓) | >11.04 | NR | .06 | NR | .86 |
| ≤11.04 | NR | NR | ||||
| ALCAM | (↓) | >10.29 | NR | .0002 | NR | .02 |
| ≤10.29 | 5 | 6 | ||||
| CCNC | (↓) | >11.71 | NR | .07 | NR | .67 |
| ≤11.71 | 9 | NR | ||||
| COPZ1 | (↓) | >11.29 | NR | .38 | NR | .71 |
| ≤11.29 | NR | NR | ||||
| FZD3 | (↓) | >9.20 | NR | .01 | NR | .18 |
| ≤9.20 | 9 | NR | ||||
| E2F5 | (↓) | >9.92 | 9 | .10 | NR | .88 |
| ≤9.92 | NR | NR | ||||
| ER related | ||||||
| PDIA5 | (↓) | >11.76 | NR | .17 | NR | .10 |
| ≤11.76 | 9 | NR | ||||
| EMC7 | (↓) | >13.72 | 9 | .11 | 7 | .77 |
| ≤13.72 | NR | NR | ||||
| PI related | ||||||
| PSMD10 | (↓) | >10.68 | 9 | .003 | NR | .25 |
| ≤10.68 | NR | NR | ||||
| SMILE/TMTC3 | (↓) | >4.0 | NR | .08 | NR | .06 |
| ≤4.0 | 9 | 6 | ||||
| PSME3 | (↓) | >8.69 | NR | .03 | NR | .33 |
| ≤8.69 | NR | NR | ||||
| PSMB6 | >12.42 | 9 | .11 | NR | .07 | |
| (↓) | ≤12.42 | NR | NR | |||
| CAV1 | (↓) | >12.46 | 7 | .11 | NR | .43 |
| ≤ 12.46 | NR | NR | ||||
| Genes . | Expression in MRD vs diagnostic clonal PCs . | Expression in TT3 patients . | TT3A (training set) . | TT3B (validation set) . | ||
|---|---|---|---|---|---|---|
| Median (years) . | P value . | Median (years) . | P value . | |||
| Cancer related | ||||||
| FERMT3 | (↑) | >9.8 | NR | .03 | NR | .03 |
| ≤9.8 | NR | NR | ||||
| TSPO | (↑) | >11.55 | 7 | .06 | 3 | .0002 |
| ≤11.55 | NR | NR | ||||
| ALOX5 | (↑) | >12.39 | NR | .07 | NR | .11 |
| ≤12.39 | NR | NR | ||||
| NCF4 | (↑) | >10.58 | NR | .09 | 7 | .2 |
| ≤10.58 | NR | NR | ||||
| FLNA | (↑) | >10.56 | 7 | .0002 | 6 | .003 |
| ≤10.56 | NR | NR | ||||
| PREX1 | (↑) | >5.33 | NR | .02 | NR | .79 |
| ≤5.33 | 7 | NR | ||||
| PYCARD | (↑) | >9.37 | 9 | .001 | NR | .35 |
| ≤9.37 | NR | NR | ||||
| MYO1G | (↑) | >4.66 | NR | .01 | NR | .09 |
| ≤4.66 | 7 | NR | ||||
| SERPINI1 | (↓) | >9.85 | NR | .11 | NR | .47 |
| ≤9.85 | NR | NR | ||||
| DUSP11 | (↓) | >11.04 | NR | .06 | NR | .86 |
| ≤11.04 | NR | NR | ||||
| ALCAM | (↓) | >10.29 | NR | .0002 | NR | .02 |
| ≤10.29 | 5 | 6 | ||||
| CCNC | (↓) | >11.71 | NR | .07 | NR | .67 |
| ≤11.71 | 9 | NR | ||||
| COPZ1 | (↓) | >11.29 | NR | .38 | NR | .71 |
| ≤11.29 | NR | NR | ||||
| FZD3 | (↓) | >9.20 | NR | .01 | NR | .18 |
| ≤9.20 | 9 | NR | ||||
| E2F5 | (↓) | >9.92 | 9 | .10 | NR | .88 |
| ≤9.92 | NR | NR | ||||
| ER related | ||||||
| PDIA5 | (↓) | >11.76 | NR | .17 | NR | .10 |
| ≤11.76 | 9 | NR | ||||
| EMC7 | (↓) | >13.72 | 9 | .11 | 7 | .77 |
| ≤13.72 | NR | NR | ||||
| PI related | ||||||
| PSMD10 | (↓) | >10.68 | 9 | .003 | NR | .25 |
| ≤10.68 | NR | NR | ||||
| SMILE/TMTC3 | (↓) | >4.0 | NR | .08 | NR | .06 |
| ≤4.0 | 9 | 6 | ||||
| PSME3 | (↓) | >8.69 | NR | .03 | NR | .33 |
| ≤8.69 | NR | NR | ||||
| PSMB6 | >12.42 | 9 | .11 | NR | .07 | |
| (↓) | ≤12.42 | NR | NR | |||
| CAV1 | (↓) | >12.46 | 7 | .11 | NR | .43 |
| ≤ 12.46 | NR | NR | ||||
NR, not reached.