Selected pathways and transcription targets predicted to be significantly inhibited according to the corresponding deregulated genes in patient-paired diagnostic vs MRD clonal PCs
| . | P value . | Genes down- or upregulated in MRD clonal PCs . |
|---|---|---|
| Pathways | ||
| Protein export | 1.50e−05 | SRPRB, SRP72, SEC61A1, SEC61G, SRP68, SPCS1, SEC11C, SPCS2, SPCS3, SEC63 |
| Protein processing in endoplasmic reticulum | 1.50e−05 | ERLEC1, SEC61G, MAN1A2, DNAJB11, SSR2, UGGT1, SEC63, EDEM2, CANX, SEC23B, OS9, SSR1, DERL1, SAR1B, RPN1, SEC61A1, STT3A, DERL2, DAD1, UBE2J1, SEL1L, EIF2S1, SSR3, LMAN2, UBE2G1, LMAN1, PDIA6 |
| N-glycan biosynthesis | .0004 | MAN2A2, RPN1, ALG5, DPM1, STT3A, ALG14, ALG13, MAN1A2, DAD1, ALG8, DOLK, ALG1 |
| Transcription targets | ||
| ELK1 | 1.91e−06 | ZNF35, TOMM20, YIPF5, PYROXD1, TRAF7, F11R, POMP, SND1, TMEM167A, HCCS, BECN1, MTMR2, UBLCP1, C14orf119, PHF5A, UBA2, DNAAF2, ATXN10, ACVR2A, RNF2, DNMT1, DDX1, RNF185, U2AF2, SLC39A9, RWDD2A, DPM1, UXT, TLK1, SDF2, TMEM59, GTF2A2, JAGN1, UBR4, NECAP2, AMZ2, TMCO1, WAS, DSCR3, TBCC, SEC61A1, C21orf59, ZBTB41, GMIP, E2F4, PEX2, POLR2H, MAD2L1BP, C11orf57, YEATS2, NXT2, CCDC25, UNC13D, MKI67IP, NDUFS1, PIGW, ZCCHC9, MUT, C17orf80, PHB2, ITFG1, UFC1, CBLL1, SDHAF2, UGGT1, HNRNPH1, SLC35A5, EIF1AD, GRPEL2, CEP164, ERH, LSM5, SHKBP1, VMP1, TMEM62, FTSJD1, COX6A1, BANF1, RPL27, FBXO38, MEA1, CKS1B, HARS2, LMAN2, MORN2, MRPL40, TOMM70A, ZNF184, MAP4K2, RHOA, PGS1, CALU, ZSCAN12, UFM1, TRMT112, TGDS, FANCF, RNF13, THUMPD3, COX17, ZFP3, RPL32, PALB2, MRPL33, LYL1, COX8A, EIF2S1, PITPNA, TXNDC12, PSME3, MRPL3 |
| . | P value . | Genes down- or upregulated in MRD clonal PCs . |
|---|---|---|
| Pathways | ||
| Protein export | 1.50e−05 | SRPRB, SRP72, SEC61A1, SEC61G, SRP68, SPCS1, SEC11C, SPCS2, SPCS3, SEC63 |
| Protein processing in endoplasmic reticulum | 1.50e−05 | ERLEC1, SEC61G, MAN1A2, DNAJB11, SSR2, UGGT1, SEC63, EDEM2, CANX, SEC23B, OS9, SSR1, DERL1, SAR1B, RPN1, SEC61A1, STT3A, DERL2, DAD1, UBE2J1, SEL1L, EIF2S1, SSR3, LMAN2, UBE2G1, LMAN1, PDIA6 |
| N-glycan biosynthesis | .0004 | MAN2A2, RPN1, ALG5, DPM1, STT3A, ALG14, ALG13, MAN1A2, DAD1, ALG8, DOLK, ALG1 |
| Transcription targets | ||
| ELK1 | 1.91e−06 | ZNF35, TOMM20, YIPF5, PYROXD1, TRAF7, F11R, POMP, SND1, TMEM167A, HCCS, BECN1, MTMR2, UBLCP1, C14orf119, PHF5A, UBA2, DNAAF2, ATXN10, ACVR2A, RNF2, DNMT1, DDX1, RNF185, U2AF2, SLC39A9, RWDD2A, DPM1, UXT, TLK1, SDF2, TMEM59, GTF2A2, JAGN1, UBR4, NECAP2, AMZ2, TMCO1, WAS, DSCR3, TBCC, SEC61A1, C21orf59, ZBTB41, GMIP, E2F4, PEX2, POLR2H, MAD2L1BP, C11orf57, YEATS2, NXT2, CCDC25, UNC13D, MKI67IP, NDUFS1, PIGW, ZCCHC9, MUT, C17orf80, PHB2, ITFG1, UFC1, CBLL1, SDHAF2, UGGT1, HNRNPH1, SLC35A5, EIF1AD, GRPEL2, CEP164, ERH, LSM5, SHKBP1, VMP1, TMEM62, FTSJD1, COX6A1, BANF1, RPL27, FBXO38, MEA1, CKS1B, HARS2, LMAN2, MORN2, MRPL40, TOMM70A, ZNF184, MAP4K2, RHOA, PGS1, CALU, ZSCAN12, UFM1, TRMT112, TGDS, FANCF, RNF13, THUMPD3, COX17, ZFP3, RPL32, PALB2, MRPL33, LYL1, COX8A, EIF2S1, PITPNA, TXNDC12, PSME3, MRPL3 |
Terms that are bold and underlined represent upregulated genes.