Comparison of blood parameters (recorded at baseline before age 3 and on hydroxyurea) of patients who reversed to abnormal TCDI on hydroxyurea vs those who did not
| Blood parameters . | Patients placed on hydroxyurea (N = 46) . | ||
|---|---|---|---|
| No reversion (n = 33), median (Q1-Q3) . | Reversion (n = 13), median (Q1-Q3) . | P* . | |
| At baseline | |||
| White blood cell count, 109/L | 14.800 (12.700-17.700) | 18.200 (11.975-20.950) | .051 |
| Neutrophil count, 109/L | 4.860 (4.205-7.297) | 6.225 (4.325-9.407) | .04 |
| Platelet count, 109/L | 354.000 (311.250-422.750) | 315.000 (262.250-349.750) | .189 |
| Hemoglobin level, g/dL | 7.8 (7.3-8.6) | 7.4 (6.7-8.0) | .074 |
| Hematocrit, % | 22.6 (21.5-25.7) | 22.0 (20.6-23.7) | .142 |
| Mean corpuscular volume, fL | 79.0 (74.4-83.1) | 82.7 (78.7-87.4) | .073 |
| Reticulocyte count, 109/L | 297.000 (248.200-355.000) | 448.100 (317.880-524.750) | .007 |
| Lactate dehydrogenase, IU/L | 974 (631-1249) | 998 (611-1267) | .656 |
| Bilirubin, mmol/L | 35 (26-50) | 26 (21-46) | .750 |
| Fetal hemoglobin, % | 13.2 (9.3-16.7) | 12.1 (9.0-15.9) | .649 |
| Recorded on hydroxyurea† | |||
| White blood cell count, 109/L | 6.700 (5.300-8.600) | 8.600 (7.200-14.925) | .002 |
| Neutrophil count, 109/L | 2.950 (2.330-3.930) | 3.655 (2.667-7.937) | .039 |
| Platelet count, 109/L | 308.000 (236.000-390.000) | 463.000 (272.250-566.500) | .011 |
| Hemoglobin level, g/dL | 8.8 (8.1-9.2) | 8.1 (7.7-8.7) | .027 |
| Hematocrit, % | 24.7 (23.2-26.2) | 23.6 (22.1-25.3) | .239 |
| Mean corpuscular volume, fL | 96.0 (81.7-101.7) | 85.5 (82.2-96.8) | .262 |
| Reticulocyte count, 109/L | 190.500 (130.800-236.100) | 172.500 (105.350-370.100) | .305 |
| Lactate dehydrogenase, IU/L | 420 (338-518) | 480 (380-530) | .348 |
| Bilirubin, mmol/L | 22 (17-56) | 23 (17-41) | .428 |
| Fetal hemoglobin, % | 14.9 (9.5-21.4) | 12.2 (5.5-20.3) | .236 |
| Hydroxyurea dose, mean mg/kg/d (SD) | 25.1 (2.2) | 23.1 (0.6) | .001 |
| Blood parameters . | Patients placed on hydroxyurea (N = 46) . | ||
|---|---|---|---|
| No reversion (n = 33), median (Q1-Q3) . | Reversion (n = 13), median (Q1-Q3) . | P* . | |
| At baseline | |||
| White blood cell count, 109/L | 14.800 (12.700-17.700) | 18.200 (11.975-20.950) | .051 |
| Neutrophil count, 109/L | 4.860 (4.205-7.297) | 6.225 (4.325-9.407) | .04 |
| Platelet count, 109/L | 354.000 (311.250-422.750) | 315.000 (262.250-349.750) | .189 |
| Hemoglobin level, g/dL | 7.8 (7.3-8.6) | 7.4 (6.7-8.0) | .074 |
| Hematocrit, % | 22.6 (21.5-25.7) | 22.0 (20.6-23.7) | .142 |
| Mean corpuscular volume, fL | 79.0 (74.4-83.1) | 82.7 (78.7-87.4) | .073 |
| Reticulocyte count, 109/L | 297.000 (248.200-355.000) | 448.100 (317.880-524.750) | .007 |
| Lactate dehydrogenase, IU/L | 974 (631-1249) | 998 (611-1267) | .656 |
| Bilirubin, mmol/L | 35 (26-50) | 26 (21-46) | .750 |
| Fetal hemoglobin, % | 13.2 (9.3-16.7) | 12.1 (9.0-15.9) | .649 |
| Recorded on hydroxyurea† | |||
| White blood cell count, 109/L | 6.700 (5.300-8.600) | 8.600 (7.200-14.925) | .002 |
| Neutrophil count, 109/L | 2.950 (2.330-3.930) | 3.655 (2.667-7.937) | .039 |
| Platelet count, 109/L | 308.000 (236.000-390.000) | 463.000 (272.250-566.500) | .011 |
| Hemoglobin level, g/dL | 8.8 (8.1-9.2) | 8.1 (7.7-8.7) | .027 |
| Hematocrit, % | 24.7 (23.2-26.2) | 23.6 (22.1-25.3) | .239 |
| Mean corpuscular volume, fL | 96.0 (81.7-101.7) | 85.5 (82.2-96.8) | .262 |
| Reticulocyte count, 109/L | 190.500 (130.800-236.100) | 172.500 (105.350-370.100) | .305 |
| Lactate dehydrogenase, IU/L | 420 (338-518) | 480 (380-530) | .348 |
| Bilirubin, mmol/L | 22 (17-56) | 23 (17-41) | .428 |
| Fetal hemoglobin, % | 14.9 (9.5-21.4) | 12.2 (5.5-20.3) | .236 |
| Hydroxyurea dose, mean mg/kg/d (SD) | 25.1 (2.2) | 23.1 (0.6) | .001 |