Biological characteristics in patients with and without abnormal velocities defined as ≥200 cm/s
| . | Patients without abnormal velocities (N = 217) . | Patients with abnormal velocities . | ||||||
|---|---|---|---|---|---|---|---|---|
| Isolated intracranial (N = 79) . | Isolated extracranial (N = 10) . | |||||||
| n . | % . | n . | % . | P* . | n . | % . | P† . | |
| Gender | ||||||||
| F | 115 | 53.0 | 38 | 48.1 | NS | 2 | 20.0 | .053 |
| M | 102 | 47 | 41 | 51.9 | 8 | 80.0 | ||
| G6PD‡ | ||||||||
| Deficiency | 16 | 8.4 | 12 | 17.4 | .041 | 1 | 14.3 | |
| Normal | 174 | 91.6 | 57 | 82.6 | 6 | 85.7 | ||
| α Genes | ||||||||
| 2 | 25 | 12.6 | 4 | 5.5 | 1 | 11.1 | ||
| 3 | 73 | 36.7 | 17 | 23.3 | 3 | 33.3 | ||
| 4 | 100 | 50.3 | 52 | 71.2 | 5 | 55.6 | ||
| 5 | 1 | 0.5 | 0 | |||||
| α-Thalassemia | ||||||||
| Absent | 101 | 50.8 | 52 | 71.2 | .004 | 5 | 55.6 | NS |
| Present | 98 | 49.2 | 21 | 28.8 | 4 | 44.4 | ||
| β Haplotype | ||||||||
| CAR/CAR | 65 | 34.8 | 33 | 45.8 | NS | 4 | 44.4 | NS |
| BEN/BEN | 53 | 28.3 | 15 | 20.8 | 1 | 11.1 | ||
| SEN/SEN | 21 | 11.2 | 5 | 6.9 | 3 | 33.3 | ||
| Others | 48 | 25.7 | 19 | 26.4 | 1 | 11.1 | ||
| . | Patients without abnormal velocities (N = 217) . | Patients with abnormal velocities . | ||||||
|---|---|---|---|---|---|---|---|---|
| Isolated intracranial (N = 79) . | Isolated extracranial (N = 10) . | |||||||
| n . | % . | n . | % . | P* . | n . | % . | P† . | |
| Gender | ||||||||
| F | 115 | 53.0 | 38 | 48.1 | NS | 2 | 20.0 | .053 |
| M | 102 | 47 | 41 | 51.9 | 8 | 80.0 | ||
| G6PD‡ | ||||||||
| Deficiency | 16 | 8.4 | 12 | 17.4 | .041 | 1 | 14.3 | |
| Normal | 174 | 91.6 | 57 | 82.6 | 6 | 85.7 | ||
| α Genes | ||||||||
| 2 | 25 | 12.6 | 4 | 5.5 | 1 | 11.1 | ||
| 3 | 73 | 36.7 | 17 | 23.3 | 3 | 33.3 | ||
| 4 | 100 | 50.3 | 52 | 71.2 | 5 | 55.6 | ||
| 5 | 1 | 0.5 | 0 | |||||
| α-Thalassemia | ||||||||
| Absent | 101 | 50.8 | 52 | 71.2 | .004 | 5 | 55.6 | NS |
| Present | 98 | 49.2 | 21 | 28.8 | 4 | 44.4 | ||
| β Haplotype | ||||||||
| CAR/CAR | 65 | 34.8 | 33 | 45.8 | NS | 4 | 44.4 | NS |
| BEN/BEN | 53 | 28.3 | 15 | 20.8 | 1 | 11.1 | ||
| SEN/SEN | 21 | 11.2 | 5 | 6.9 | 3 | 33.3 | ||
| Others | 48 | 25.7 | 19 | 26.4 | 1 | 11.1 | ||
Three of 92 patients had both intra- and extracranial abnormal TCDI and are not reported in this table.
BEN, Benin; CAR, Central African Republic; G6PD, glucose-6-phosphate dehydrogenase; NS, not significant SEN, Senegal.
Comparison of variable distribution between patients without abnormal velocities and those with isolated intracranial abnormal velocities. Bold type denotes statistically significant.
Comparison of variable distribution between patients without abnormal velocities and those with isolated extracranial abnormal velocities.
G6PD activity was assessed at baseline, a minimum of 3 mo away from a transfusion by reduction of nicotinamide adenine dinucleotide phosphate (NADP) to NADPH, measured by UV spectrophotometry.