Recommended site-specific workup in MALT lymphomas
| MALT lymphoma site . | Site-specific staging procedures . |
|---|---|
| Stomach | Ear/nose/throat examination, EGD, endoscopic ultrasound to evaluate regional lymph nodes and gastric wall infiltration, search for H pylori (histochemistry, serology, breath test, fecal antigen), search for MALT1 translocation by FISH |
| Salivary glands | Ear/nose/throat examination and ultrasound. Anti-SSA or anti-SSB antibodies for possible association with Sjögren syndrome |
| Thyroid | Ultrasound ± CT scan of the neck and thyroid function tests |
| Lung | Bronchoscopy with bronchoalveolar lavage |
| Small intestine | Search for C jejuni in the tumor biopsy (PCR, immunohistochemistry or in situ hybridization) |
| Large intestine | Colonoscopy |
| Breast | Mammography and MRI |
| Ocular adnexa | MRI and ophthalmologic examination. Search for C psittaci in the tumor biopsy and blood mononuclear cells by PCR may be considered |
| Skin | Search for B burgdorferi in the tumor biopsy by PCR may be considered in areas where it is endemic |
| MALT lymphoma site . | Site-specific staging procedures . |
|---|---|
| Stomach | Ear/nose/throat examination, EGD, endoscopic ultrasound to evaluate regional lymph nodes and gastric wall infiltration, search for H pylori (histochemistry, serology, breath test, fecal antigen), search for MALT1 translocation by FISH |
| Salivary glands | Ear/nose/throat examination and ultrasound. Anti-SSA or anti-SSB antibodies for possible association with Sjögren syndrome |
| Thyroid | Ultrasound ± CT scan of the neck and thyroid function tests |
| Lung | Bronchoscopy with bronchoalveolar lavage |
| Small intestine | Search for C jejuni in the tumor biopsy (PCR, immunohistochemistry or in situ hybridization) |
| Large intestine | Colonoscopy |
| Breast | Mammography and MRI |
| Ocular adnexa | MRI and ophthalmologic examination. Search for C psittaci in the tumor biopsy and blood mononuclear cells by PCR may be considered |
| Skin | Search for B burgdorferi in the tumor biopsy by PCR may be considered in areas where it is endemic |
EGD, esophagogastroduodenoscopy; FISH, fluorescence in situ hybridization; MRI, magnetic resonance imaging; PCR, polymerase chain reaction; SSA, Sjögren syndrome A; SSB, Sjögren syndrome B.