Table 1 Most common genetic aberrations... | American Society of Hematology

Table 1

Most common genetic aberrations detected in MALT lymphomas

Genetic lesion^3-22	Involved genes	Deregulated pathway	Prevalence, %	Anatomical sites	Clinical relevance
t(11;18)(q21;q21)	BIRC3-MALT1	NF-κB	15-40	Stomach, lung	Antibiotic resistance alkylating agents resistance?
t(14;18)(q32;q21)	IGHV-MALT1	NF-κB	20	Lung, salivary gland, skin, ocular adnexa	Antibiotic resistance?
t(1;14)(p22;q32)	IGHV-BCL10	NF-κB	<5	Stomach, lung	Antibiotic resistance
t(3;14)(p13;q32)	IGHV-FOXP1	Wnt*	<5	Unclear	Transformation risk?
t(9;14)(p24;q32)	IGHV-JMJD2C	Chromatin remodeling†	<5	Unclear
t(X;14)(p11;q32)	IGHV-GPR34	NF-κB ?	<5	Unclear
t(5;14)(q34;q32)	IGHV- TENM2	Unclear	<5	Unclear
Trisomy 3	Unclear	Unclear	20-40	Equal distribution	Inferior outcome?
Trisomy 18	Unclear	Unclear	20-40	Equal distribution
del(6q23)	TNFAIP3	NF-κB	15-30	Equal distribution

Genetic lesion^3-22	Involved genes	Deregulated pathway	Prevalence, %	Anatomical sites	Clinical relevance
t(11;18)(q21;q21)	BIRC3-MALT1	NF-κB	15-40	Stomach, lung	Antibiotic resistance alkylating agents resistance?
t(14;18)(q32;q21)	IGHV-MALT1	NF-κB	20	Lung, salivary gland, skin, ocular adnexa	Antibiotic resistance?
t(1;14)(p22;q32)	IGHV-BCL10	NF-κB	<5	Stomach, lung	Antibiotic resistance
t(3;14)(p13;q32)	IGHV-FOXP1	Wnt*	<5	Unclear	Transformation risk?
t(9;14)(p24;q32)	IGHV-JMJD2C	Chromatin remodeling†	<5	Unclear
t(X;14)(p11;q32)	IGHV-GPR34	NF-κB ?	<5	Unclear
t(5;14)(q34;q32)	IGHV- TENM2	Unclear	<5	Unclear
Trisomy 3	Unclear	Unclear	20-40	Equal distribution	Inferior outcome?
Trisomy 18	Unclear	Unclear	20-40	Equal distribution
del(6q23)	TNFAIP3	NF-κB	15-30	Equal distribution

DLBCLs bearing the same chromosomal translocation show deregulated Wnt signaling.²¹

†

JMJD2C is amplified and overexpressed in other lymphoma subtypes in which its genetic silencing leads to decreased levels of H3K9me3, a marker of transcriptional repression.²²

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