Cytogenetic abnormalities in GATA2-related childhood MDS
| Karyotype . | Patients, N (%) N = 56 . | MDS subtype . | |
|---|---|---|---|
| RCC . | RAEB/RAEB-t . | ||
| Monosomy 7* | 38 (68%) | 17 | 16/5 |
| Der(1;7)(q10;p10)† | 4 (7%) | 1 | 3/0 |
| Trisomy 8‡ | 5 (9%) | 3 | 1/1 |
| Normal | 9 (16%) | 9 | 0/0 |
| Karyotype . | Patients, N (%) N = 56 . | MDS subtype . | |
|---|---|---|---|
| RCC . | RAEB/RAEB-t . | ||
| Monosomy 7* | 38 (68%) | 17 | 16/5 |
| Der(1;7)(q10;p10)† | 4 (7%) | 1 | 3/0 |
| Trisomy 8‡ | 5 (9%) | 3 | 1/1 |
| Normal | 9 (16%) | 9 | 0/0 |
Karyotypes were available for 56 of 57 GATA2-deficient patients.
Includes 5 patients with an additional aberration [trisomy 8, trisomy 21, trisomy 22, del(12)(p11p13), del(18q)].
Includes 2 patients with additional trisomy 8 and 1 patient each with trisomy 11 or a marker chromosome.
Includes 1 patient with a marker chromosome.