Conditioning combinations used in patients with newly diagnosed or relapsed PCNSL
| Regimens . |
|---|
| Without thiotepa |
| BEAM regimen20,21 |
| BCNU, 300 mg/m2, day −7 |
| Etoposide, 100 mg/m2 every 12 h, days −6 to −3 |
| Cytarabine, 200 mg/m2 every 12 h, days −6 to −3 |
| Melphalan, 140 mg/m2, day −2 |
| BUCYE regimen23 |
| Busulfan, 3.2 mg/kg per day, days −7 to −5 |
| Cyclophosphamide, 50 mg/kg per d, days −3 and −2 |
| Etoposide, 200 mg/m2, twice a day, days −5 and −4 |
| LEED regimen24 |
| Cyclophosphamide, 60 mg/kg per day, days −4 and −3 |
| Etoposide, 250 mg/m2 every 12 h, days −4 to −2 |
| Melphalan, 130 mg/m2, once daily, day −1 |
| Dexamethasone, 48 mg/d, days −4 to −1 |
| Containing thiotepa |
| Busulfan-thiotepa combination25 |
| Busulfan, 4 oral daily doses of 4 mg/kg BW/d, days −8 to −50 |
| Thiotepa, 5 mg/kg body weight, days −4 and −3 |
| TBC regimen27,28,43 |
| Thiotepa, 250-300 mg/m2 per day, days –8 and –7 |
| Busulfan, 3.2-9.6 mg/kg BW/d, days –6 to –4 |
| Cyclophosphamide, 2 g/m2 per day, days –3 and –2 |
| TBC regimen26 |
| Thiotepa, 250 mg/m2 per day, days −9, −8, and −7 |
| Busulfan, 3.2 mg/kg per day, days −6, −5, and −4 |
| Cyclophosphamide, 60 mg/kg per day, days −3 and −2 |
| BCNU-thiotepa regimen29 |
| Carmustine, 400 mg/m2, day −6 |
| Thiotepa, 5 mg/kg BW/d, days −5 and −4 |
| BCNU-thiotepa 10 regimen6 |
| Carmustine, 400 mg/m2, day −6 |
| Thiotepa, 2 × 5 mg/kg BW/d, days −5 and −4 |
| Regimens . |
|---|
| Without thiotepa |
| BEAM regimen20,21 |
| BCNU, 300 mg/m2, day −7 |
| Etoposide, 100 mg/m2 every 12 h, days −6 to −3 |
| Cytarabine, 200 mg/m2 every 12 h, days −6 to −3 |
| Melphalan, 140 mg/m2, day −2 |
| BUCYE regimen23 |
| Busulfan, 3.2 mg/kg per day, days −7 to −5 |
| Cyclophosphamide, 50 mg/kg per d, days −3 and −2 |
| Etoposide, 200 mg/m2, twice a day, days −5 and −4 |
| LEED regimen24 |
| Cyclophosphamide, 60 mg/kg per day, days −4 and −3 |
| Etoposide, 250 mg/m2 every 12 h, days −4 to −2 |
| Melphalan, 130 mg/m2, once daily, day −1 |
| Dexamethasone, 48 mg/d, days −4 to −1 |
| Containing thiotepa |
| Busulfan-thiotepa combination25 |
| Busulfan, 4 oral daily doses of 4 mg/kg BW/d, days −8 to −50 |
| Thiotepa, 5 mg/kg body weight, days −4 and −3 |
| TBC regimen27,28,43 |
| Thiotepa, 250-300 mg/m2 per day, days –8 and –7 |
| Busulfan, 3.2-9.6 mg/kg BW/d, days –6 to –4 |
| Cyclophosphamide, 2 g/m2 per day, days –3 and –2 |
| TBC regimen26 |
| Thiotepa, 250 mg/m2 per day, days −9, −8, and −7 |
| Busulfan, 3.2 mg/kg per day, days −6, −5, and −4 |
| Cyclophosphamide, 60 mg/kg per day, days −3 and −2 |
| BCNU-thiotepa regimen29 |
| Carmustine, 400 mg/m2, day −6 |
| Thiotepa, 5 mg/kg BW/d, days −5 and −4 |
| BCNU-thiotepa 10 regimen6 |
| Carmustine, 400 mg/m2, day −6 |
| Thiotepa, 2 × 5 mg/kg BW/d, days −5 and −4 |
BW/d, body weight per day; TBC, thiotepa, busulfan, and cyclophosphamide.