Germinal center- or postgerminal center-derived lymphomas in HIV-infected individuals: immunodeficiency level, phenotypic features, and genetic abnormalities
| . | Germinal center . | Postgerminal center . | |||
|---|---|---|---|---|---|
| . | Germinal center B-cell type . | Activated B-cell type . | Plasmablastic type/plasma cell type . | ||
| Histotype | BL | DLBCL-CB | DLBCL-IB | PBL | PEL |
| Phenotypic features | |||||
| BCL-6 | + | + | — | — | — |
| MUM1 | — | — | + | + | + |
| CD138 | — | — | −/+ | +/− | + |
| Genetic abnormalities | |||||
| BCL-2 | — | — | 30% | 20% | — |
| BCL-6 | 100% | >75% | — | <10% | — |
| TP53 | 50-60% | Rare | — | — | — |
| MYC | 100% | 0-50% | — | 40% | — |
| . | Germinal center . | Postgerminal center . | |||
|---|---|---|---|---|---|
| . | Germinal center B-cell type . | Activated B-cell type . | Plasmablastic type/plasma cell type . | ||
| Histotype | BL | DLBCL-CB | DLBCL-IB | PBL | PEL |
| Phenotypic features | |||||
| BCL-6 | + | + | — | — | — |
| MUM1 | — | — | + | + | + |
| CD138 | — | — | −/+ | +/− | + |
| Genetic abnormalities | |||||
| BCL-2 | — | — | 30% | 20% | — |
| BCL-6 | 100% | >75% | — | <10% | — |
| TP53 | 50-60% | Rare | — | — | — |
| MYC | 100% | 0-50% | — | 40% | — |
Immunodeficiency increases from mild (left) to severe (right) across the table.
−, absent; +, present; +/−, usually present; −/+, usually absent.