In vivo NPM-ALK lymphoma dissemination
| Genotype . | Cre . | Spleen . | Liver . | Kidney . | Lung . | Bone marrow . | Brain . | Heart . |
|---|---|---|---|---|---|---|---|---|
| NPM-ALK | CD4Cre | 4/4 | 4/4 | 4/4 | 4/4 | 4/4 | 0/4 | 0/4 |
| NPM-ALK;Cdc42fl/fl | CD4Cre | 3/3 | 3/3 | 3/3 | 3/3 | 3/3 | 0/3 | 0/3 |
| NPM-ALK;Rac1fl/fl | CD4Cre | 3/3 | 3/3 | 3/3 | 3/3 | 3/3 | 0/3 | 0/3 |
| NPM-ALK;Cdc42fl/fl | CreERT2 | 3/3 | 3/3 | 3/3 | 0/3 | 3/3 | 0/3 | 0/3 |
| NPM-ALK;Rac1fl/fl | CreERT2 | 3/3 | 3/3 | 3/3 | 2/3 | 3/3 | 0/3 | 0/3 |
| NPM-ALK;Cdc42fl/fl;Rac1fl/fl | CreERT2 | 0/6 | 0/6 | 0/6 | 1/6 | 0/6 | 0/6 | 0/6 |
| Genotype . | Cre . | Spleen . | Liver . | Kidney . | Lung . | Bone marrow . | Brain . | Heart . |
|---|---|---|---|---|---|---|---|---|
| NPM-ALK | CD4Cre | 4/4 | 4/4 | 4/4 | 4/4 | 4/4 | 0/4 | 0/4 |
| NPM-ALK;Cdc42fl/fl | CD4Cre | 3/3 | 3/3 | 3/3 | 3/3 | 3/3 | 0/3 | 0/3 |
| NPM-ALK;Rac1fl/fl | CD4Cre | 3/3 | 3/3 | 3/3 | 3/3 | 3/3 | 0/3 | 0/3 |
| NPM-ALK;Cdc42fl/fl | CreERT2 | 3/3 | 3/3 | 3/3 | 0/3 | 3/3 | 0/3 | 0/3 |
| NPM-ALK;Rac1fl/fl | CreERT2 | 3/3 | 3/3 | 3/3 | 2/3 | 3/3 | 0/3 | 0/3 |
| NPM-ALK;Cdc42fl/fl;Rac1fl/fl | CreERT2 | 0/6 | 0/6 | 0/6 | 1/6 | 0/6 | 0/6 | 0/6 |