Multivariate analysis: risks of acute and chronic GVHD, nonrelapse mortality, relapse, and OS by donor type
| . | Transplant conditioning regimen intensity . | |
|---|---|---|
| Outcome . | Myeloablative* . | Reduced intensity† . |
| Hazard ratio (95% CI) . | Hazard ratio (95% CI) . | |
| Grade 2-4 acute GVHD | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 0.40 (0.26-0.62) | 0.68 (0.46-1.00) |
| P <.0001 | P = .05 | |
| Grade 3-4 acute GVHD | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 0.47 (0.23-0.94) | 0.20 (0.06-0.64) |
| P = .03 | P = .006 | |
| Chronic GVHD | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 0.46 (0.32-0.67) | 0.51 (0.35-0.75) |
| P <.0001 | P = .0006 | |
| Nonrelapse mortality | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 0.76 (0.45-1.28) | 0.41 (0.20-0.83) |
| P = .31 | P = .01 | |
| Relapse | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 1.12 (0.83-1.52) | 1.36 (1.00-1.85) |
| P = .46 | P = .05 | |
| Overall mortality | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 1.08 (0.82-1.43) | 0.94 (0.70-1.27) |
| P = .58 | P = .70 | |
| . | Transplant conditioning regimen intensity . | |
|---|---|---|
| Outcome . | Myeloablative* . | Reduced intensity† . |
| Hazard ratio (95% CI) . | Hazard ratio (95% CI) . | |
| Grade 2-4 acute GVHD | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 0.40 (0.26-0.62) | 0.68 (0.46-1.00) |
| P <.0001 | P = .05 | |
| Grade 3-4 acute GVHD | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 0.47 (0.23-0.94) | 0.20 (0.06-0.64) |
| P = .03 | P = .006 | |
| Chronic GVHD | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 0.46 (0.32-0.67) | 0.51 (0.35-0.75) |
| P <.0001 | P = .0006 | |
| Nonrelapse mortality | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 0.76 (0.45-1.28) | 0.41 (0.20-0.83) |
| P = .31 | P = .01 | |
| Relapse | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 1.12 (0.83-1.52) | 1.36 (1.00-1.85) |
| P = .46 | P = .05 | |
| Overall mortality | ||
| Matched unrelated donor | 1.00 | 1.00 |
| Haploidentical donor | 1.08 (0.82-1.43) | 0.94 (0.70-1.27) |
| P = .58 | P = .70 | |
Nonrelapse mortality risk adjusted for performance score; relapse risk adjusted for disease risk index; overall mortality adjusted for patient age and disease risk index.
Nonrelapse mortality risk adjusted for disease risk index; relapse risk adjusted for performance score, disease risk index, and secondary AML; overall mortality adjusted for disease risk index and secondary AML.