Genomic alterations in CRLF2-rearranged Ph-like ALL specimens used for patient-derived xenograft models
| Specimen . | USI . | Source . | CRLF2 rearrangement . | JAK mutation . | Other mutations . |
|---|---|---|---|---|---|
| JH331 | PAMDKS | de novo | IGH@-CRLF2 | JAK2 R683G | IKZF1, PAX5, CDKN2A |
| JH352 | PALJCF | de novo | P2RY8-CRLF2 | JAK1 L624_R629 > W | CDKN2A/B |
| NH362 | PALTWS | de novo | IGH@-CRLF2 | Negative | IKZF1, PAX5, CDKN2A |
| ALL4364 | n/a | relapse | P2RY8-CRLF2 | JAK2 R683G |
| Specimen . | USI . | Source . | CRLF2 rearrangement . | JAK mutation . | Other mutations . |
|---|---|---|---|---|---|
| JH331 | PAMDKS | de novo | IGH@-CRLF2 | JAK2 R683G | IKZF1, PAX5, CDKN2A |
| JH352 | PALJCF | de novo | P2RY8-CRLF2 | JAK1 L624_R629 > W | CDKN2A/B |
| NH362 | PALTWS | de novo | IGH@-CRLF2 | Negative | IKZF1, PAX5, CDKN2A |
| ALL4364 | n/a | relapse | P2RY8-CRLF2 | JAK2 R683G |
n/a, not available; USI, unique specimen identifier (Children’s Oncology Group).