Factors associated with RFS in 49 patients with mastocytosis treated by 2-CdA
| Covariates . | HR . | 95% CI . | P . |
|---|---|---|---|
| Male gender | 0.69 | 0.34-1.42 | .31 |
| AHNMD vs ISM/SSM/CM/MIS | 0.66 | 0.25-1.73 | .40 |
| ASM vs ISM/SSM/CM/MIS | 1.20 | 0.46-3.18 | .71 |
| Age at mastocytosis diagnosis >50 y | 1.25 | 0.62-2.52 | .53 |
| Age at 2-CdA initiation >55 y | 0.73 | 0.36-1.49 | .39 |
| Fatigue | 0.84 | 0.38-1.86 | .66 |
| Flush | 1.22 | 0.61-2.46 | .58 |
| Pruritus | 1.61 | 0.79-3.29 | .19 |
| Abdominal pain | 1.82 | 0.91-3.63 | .09 |
| Diarrhea | 1.39 | 0.69-2.81 | .36 |
| Hepatosplenomegaly | 1.06 | 0.53-2.09 | .88 |
| Urticaria pigmentosa | 1.42 | 0.70-0.55 | .46 |
| Bone involvement (yes vs no) | 0.50 | 0.24-1.04 | .06 |
| Anemia <10g/dL | 1.18 | 0.49-2.88 | .71 |
| >3 courses of 2-CdA | 1.72 | 0.84-3.49 | .14 |
| >4 courses of 2-CdA | 2.79 | 1.30-6.02 | .009 |
| Partial response | 2.16 | 1.05-4.44 | .037 |
| Covariates . | HR . | 95% CI . | P . |
|---|---|---|---|
| Male gender | 0.69 | 0.34-1.42 | .31 |
| AHNMD vs ISM/SSM/CM/MIS | 0.66 | 0.25-1.73 | .40 |
| ASM vs ISM/SSM/CM/MIS | 1.20 | 0.46-3.18 | .71 |
| Age at mastocytosis diagnosis >50 y | 1.25 | 0.62-2.52 | .53 |
| Age at 2-CdA initiation >55 y | 0.73 | 0.36-1.49 | .39 |
| Fatigue | 0.84 | 0.38-1.86 | .66 |
| Flush | 1.22 | 0.61-2.46 | .58 |
| Pruritus | 1.61 | 0.79-3.29 | .19 |
| Abdominal pain | 1.82 | 0.91-3.63 | .09 |
| Diarrhea | 1.39 | 0.69-2.81 | .36 |
| Hepatosplenomegaly | 1.06 | 0.53-2.09 | .88 |
| Urticaria pigmentosa | 1.42 | 0.70-0.55 | .46 |
| Bone involvement (yes vs no) | 0.50 | 0.24-1.04 | .06 |
| Anemia <10g/dL | 1.18 | 0.49-2.88 | .71 |
| >3 courses of 2-CdA | 1.72 | 0.84-3.49 | .14 |
| >4 courses of 2-CdA | 2.79 | 1.30-6.02 | .009 |
| Partial response | 2.16 | 1.05-4.44 | .037 |
AHNMD, associated hematologic non–mast cell disease; ASM, aggressive systemic mastocytosis; CM, cutaneous mastocytosis; ISM, indolent systemic mastocytosis; MIS, mastocytosis in the skin; SSM, smoldering systemic mastocytosis
Bold indicates significant parameters in univariate analysis.