Characteristics of myelodysplasia in humans and mice
| Lineage . | Human* . | Mouse† . |
|---|---|---|
| Erythroid | Binucleated erythroid percursors | Multinucleated erythroid precursors |
| Nuclear budding, nuclear strings or internuclear bridging | Karyorrhexis | |
| Karyorrhexis | Irregular nuclear contours | |
| Cytoplasmic fraying | Ringed sideroblasts | |
| ≥15% ringed sideroblasts | Megaloblastic change with asynchrony | |
| Granulocytic | Hypersegmented nuclei | Abnormal cytoplasmic maturation |
| Hyposegmented nuclei | Abnormal nuclear maturation | |
| Pseudo-Pelger-Huet anomaly | Hypersegmentation | |
| Abnormal granulation: hypogranulation, pseudo Chediak-Higashi large granules, dimorphic granules (basophilic and eosinophilic granules) within eosinophils | ||
| Auer rods | ||
| Megakaryocytic | Hypersegmented nuclei | Strange hypersegmentation |
| Hyposegmented nuclei | Unilobulated nuclei | |
| Multiple separated nuclei | Multiple separated nuclei | |
| Micromegakaryocytes | Micromegakaryocytes | |
| Ballooning of platelets |
| Lineage . | Human* . | Mouse† . |
|---|---|---|
| Erythroid | Binucleated erythroid percursors | Multinucleated erythroid precursors |
| Nuclear budding, nuclear strings or internuclear bridging | Karyorrhexis | |
| Karyorrhexis | Irregular nuclear contours | |
| Cytoplasmic fraying | Ringed sideroblasts | |
| ≥15% ringed sideroblasts | Megaloblastic change with asynchrony | |
| Granulocytic | Hypersegmented nuclei | Abnormal cytoplasmic maturation |
| Hyposegmented nuclei | Abnormal nuclear maturation | |
| Pseudo-Pelger-Huet anomaly | Hypersegmentation | |
| Abnormal granulation: hypogranulation, pseudo Chediak-Higashi large granules, dimorphic granules (basophilic and eosinophilic granules) within eosinophils | ||
| Auer rods | ||
| Megakaryocytic | Hypersegmented nuclei | Strange hypersegmentation |
| Hyposegmented nuclei | Unilobulated nuclei | |
| Multiple separated nuclei | Multiple separated nuclei | |
| Micromegakaryocytes | Micromegakaryocytes | |
| Ballooning of platelets |