Diagnostic criteria for MDS in humans and mice
| . | Human* . | Mouse† . |
|---|---|---|
| Necessary criteria | ||
| Cytopenia in at least one lineage | Anemia (Hb <11 g/dL) | Anemia‡ (without leukocytosis or thrombocytosis) |
| Neutropenia (ANC <1500/µL) | Neutropenia‡ (with or without anemia or thrombocytopenia) | |
| Thrombocytopenia (PLT <1 × 105/µL) | Thrombocytopenia‡ (without leukocytosis or erythrocytosis | |
| Dyspoiesis in at least one lineage | >10% dysplastic cells in ≥1 lineage | Dyspoiesis with or without increased numbers of immature nonlymphoid cells |
| Supportive criteria | Molecular evidence of a monoclonal cell population | Molecular evidence of a monoclonal cell population |
| Persistent decrease in colony-forming hematopoietic progenitors | ||
| Exclusion criteria | Other disorders that can cause cytopenia or dysplasia | >20% nonlymphoid blasts in the marrow or spleen (suggesting a nonlymphoid leukemia) |
| . | Human* . | Mouse† . |
|---|---|---|
| Necessary criteria | ||
| Cytopenia in at least one lineage | Anemia (Hb <11 g/dL) | Anemia‡ (without leukocytosis or thrombocytosis) |
| Neutropenia (ANC <1500/µL) | Neutropenia‡ (with or without anemia or thrombocytopenia) | |
| Thrombocytopenia (PLT <1 × 105/µL) | Thrombocytopenia‡ (without leukocytosis or erythrocytosis | |
| Dyspoiesis in at least one lineage | >10% dysplastic cells in ≥1 lineage | Dyspoiesis with or without increased numbers of immature nonlymphoid cells |
| Supportive criteria | Molecular evidence of a monoclonal cell population | Molecular evidence of a monoclonal cell population |
| Persistent decrease in colony-forming hematopoietic progenitors | ||
| Exclusion criteria | Other disorders that can cause cytopenia or dysplasia | >20% nonlymphoid blasts in the marrow or spleen (suggesting a nonlymphoid leukemia) |
ANC, absolute neutrophil count; cytopenia, reduced number of blood cells; cytosis, increased number of blood cells; dyspoiesis, abnormal cellular maturation; Hb, hemoglobin; PLT, platelet.
Data adapted from Vardiman et al.39,40,43
Data adapted from Kogan et al.18
Threshold numbers are not provided here because they differ for each mouse strain. For information about normal values for particular mouse strains, please see Russell and Bernstein.44