Univariate analysis (life tables and log-rank test) of the difference between OS and PFS according to dichotomized baseline PET parameters and the presence of a bulky lesion
| Parameter . | 5-y OS (95% CI) . | P . | 5-y PFS (95% CI) . | P . |
|---|---|---|---|---|
| SUVmax | .0025 | .0065 | ||
| Low | 99% (91%-99.8%) | 93% (84%-97%) | ||
| High | 83% (64%-93%) | 73% (54%-86%) | ||
| MTV | .0036 | <.0001 | ||
| Low | 100% (n.a.%) | 95% (88%-98%) | ||
| High | 86% (72%-94%) | 55% (31%-73%) | ||
| TLG | .0001 | <.0001 | ||
| Low | 100% (n.a.%) | 99% (90%-99.8%) | ||
| High | 80% (62%-91%) | 64% (45%-77%) | ||
| Bulky disease | .120 | .013 | ||
| <10 cm | 98% (86%-99%) | 96% (85%-99%) | ||
| ≥10 cm | 91% (79%-96%) | 80% (66%-88%) |
| Parameter . | 5-y OS (95% CI) . | P . | 5-y PFS (95% CI) . | P . |
|---|---|---|---|---|
| SUVmax | .0025 | .0065 | ||
| Low | 99% (91%-99.8%) | 93% (84%-97%) | ||
| High | 83% (64%-93%) | 73% (54%-86%) | ||
| MTV | .0036 | <.0001 | ||
| Low | 100% (n.a.%) | 95% (88%-98%) | ||
| High | 86% (72%-94%) | 55% (31%-73%) | ||
| TLG | .0001 | <.0001 | ||
| Low | 100% (n.a.%) | 99% (90%-99.8%) | ||
| High | 80% (62%-91%) | 64% (45%-77%) | ||
| Bulky disease | .120 | .013 | ||
| <10 cm | 98% (86%-99%) | 96% (85%-99%) | ||
| ≥10 cm | 91% (79%-96%) | 80% (66%-88%) |
The presence of a bulky lesion was statistically significant only for PFS. All the remaining baseline clinical parameters, namely, gender, age, performance status, B-symptoms, LDH, stage, and the international prognostic indices, had no statistically significant impact on both OS and PFS and are not included in this table but are reported in the online appendices. Cutoff values used for the dichotomization of functional PET parameters (SUVmax, MTV, TLG) are reported in Table 2.