Multivariable Cox regression analyses for overall survival including CDKN2A deletion and TP53 deletion status, excluding or including Ki-67 index (in %), without or with adjustment for MIPI score
| Variable . | Adjustment . | OS . | |||
|---|---|---|---|---|---|
| HR . | 95% CI (lower bound) . | 95% CI, upper bound . | P . | ||
| CDKN2A deletion | None | 5.51 | 2.42 | 12.54 | <.001 |
| TP53 deletion | 2.92 | 1.23 | 6.93 | .015 | |
| CDKN2A deletion | MIPI score | 4.46 | 1.85 | 10.78 | .001 |
| TP53 deletion | 2.86 | 1.20 | 6.80 | .017 | |
| CDKN2A deletion | None | 4.15 | 1.55 | 11.14 | .005 |
| TP53 deletion | 2.54 | 1.04 | 6.24 | .041 | |
| Ki-67 index (10% increase) | 1.11 | 0.92 | 1.33 | .27 | |
| CDKN2A deletion | MIPI score | 4.19 | 1.50 | 11.66 | .006 |
| TP53 deletion | 2.79 | 1.15 | 6.78 | .024 | |
| Ki-67 index (10% increase) | 1.03 | 0.83 | 1.28 | .81 | |
| Variable . | Adjustment . | OS . | |||
|---|---|---|---|---|---|
| HR . | 95% CI (lower bound) . | 95% CI, upper bound . | P . | ||
| CDKN2A deletion | None | 5.51 | 2.42 | 12.54 | <.001 |
| TP53 deletion | 2.92 | 1.23 | 6.93 | .015 | |
| CDKN2A deletion | MIPI score | 4.46 | 1.85 | 10.78 | .001 |
| TP53 deletion | 2.86 | 1.20 | 6.80 | .017 | |
| CDKN2A deletion | None | 4.15 | 1.55 | 11.14 | .005 |
| TP53 deletion | 2.54 | 1.04 | 6.24 | .041 | |
| Ki-67 index (10% increase) | 1.11 | 0.92 | 1.33 | .27 | |
| CDKN2A deletion | MIPI score | 4.19 | 1.50 | 11.66 | .006 |
| TP53 deletion | 2.79 | 1.15 | 6.78 | .024 | |
| Ki-67 index (10% increase) | 1.03 | 0.83 | 1.28 | .81 | |