Sequences of peptides corresponding to regions encoded by ns-SNPs
| Peptide pool . | Peptides . | FVIII residues . | Sequence* . |
|---|---|---|---|
| F8 ns-SNP pool 1 | F8-M2238-1 | 2224-2243 | NNPKEWLQVDFQKTMKVTGV |
| F8-M2238V-1 | 2224-2243 | NNPKEWLQVDFQKTVKVTGV | |
| F8-M2238-2 | 2232-2251 | VDFQKTMKVTGVTTQGVKSL | |
| F8-M2238V-2 | 2232-2251 | VDFQKTVKVTGVTTQGVKSL | |
| F8 ns-SNP pool 2 | F8-R484-1 | 470-489 | SRPYNIYPHGITDVRPLYSR |
| F8-R484H-1 | 470-489 | SRPYNIYPHGITDVHPLYSR | |
| F8-R484-2 | 478-497 | HGITDVRPLYSRRLPKGVKH | |
| F8-R484H-2 | 478-497 | HGITDVHPLYSRRLPKGVKH | |
| F8 ns-SNP pool 3 | F8-R776-1 | 762-781 | PENDIEKTDPWFAHRTPMPK |
| F8-R776G-1 | 762-781 | PENDIEKTDPWFAHGTPMPK | |
| F8-R776-2 | 770-789 | DPWFAHRTPMPKIQNVSSSD | |
| F8-R776G-2 | 770-789 | DPWFAHGTPMPKIQNVSSSD | |
| F8 ns-SNP pool 4 | F8-D1241-1 | 1227-1246 | LFLLSTRQNVEGSYDGAYAP |
| F8-D1241E-1 | 1227-1246 | LFLLSTRQNVEGSYEGAYAP | |
| F8-D1241-2 | 1235-1254 | NVEGSYDGAYAPVLQDFRSL | |
| F8-D1241E-2 | 1235-1254 | NVEGSYEGAYAPVLQDFRSL |
| Peptide pool . | Peptides . | FVIII residues . | Sequence* . |
|---|---|---|---|
| F8 ns-SNP pool 1 | F8-M2238-1 | 2224-2243 | NNPKEWLQVDFQKTMKVTGV |
| F8-M2238V-1 | 2224-2243 | NNPKEWLQVDFQKTVKVTGV | |
| F8-M2238-2 | 2232-2251 | VDFQKTMKVTGVTTQGVKSL | |
| F8-M2238V-2 | 2232-2251 | VDFQKTVKVTGVTTQGVKSL | |
| F8 ns-SNP pool 2 | F8-R484-1 | 470-489 | SRPYNIYPHGITDVRPLYSR |
| F8-R484H-1 | 470-489 | SRPYNIYPHGITDVHPLYSR | |
| F8-R484-2 | 478-497 | HGITDVRPLYSRRLPKGVKH | |
| F8-R484H-2 | 478-497 | HGITDVHPLYSRRLPKGVKH | |
| F8 ns-SNP pool 3 | F8-R776-1 | 762-781 | PENDIEKTDPWFAHRTPMPK |
| F8-R776G-1 | 762-781 | PENDIEKTDPWFAHGTPMPK | |
| F8-R776-2 | 770-789 | DPWFAHRTPMPKIQNVSSSD | |
| F8-R776G-2 | 770-789 | DPWFAHGTPMPKIQNVSSSD | |
| F8 ns-SNP pool 4 | F8-D1241-1 | 1227-1246 | LFLLSTRQNVEGSYDGAYAP |
| F8-D1241E-1 | 1227-1246 | LFLLSTRQNVEGSYEGAYAP | |
| F8-D1241-2 | 1235-1254 | NVEGSYDGAYAPVLQDFRSL | |
| F8-D1241E-2 | 1235-1254 | NVEGSYEGAYAPVLQDFRSL |
The polymorphic sequences at FVIII residues 484, 776, 1241, and 2238 are bolded.