Hematologic parameters of SCD mice treated with RN-1
| . | . | 2 weeks . | . | . | 4 weeks . | . |
|---|---|---|---|---|---|---|
| RN-1 (μg/g) | 0 | 3 | 10 | 0 | 3 | 10 |
| RBC (× 106 cells/μL) | 7.15 ± 1.89 | 7.32 ± 0.69 | 8.02 ± 0.67 | 7.52 ± 0.90 | 7.66 ± 1.09 | 8.00 ± 2.21 |
| HGB (g/dL) | 5.00 ± 1.82 | 5.60 ± 0.89 | 6.00 ± 0.71 | 5.50 ± 0.70 | 6.00 ± 1.22 | 6.33 ± 1.52 |
| HCT (%) | 33.8 ± 8.95 | 38.00 ± 2.91 | 38.80 ± 3.03 | 38.70 ± 9.71 | 37.2 ± 4.32 | 37.5 ± 3.11 |
| MCV (fL) | 47.13 ± 1.72 | 51.92 ± 3.51* | 48.14 ± 0.78 | 48.93 ± 3.79 | 49.84 ± 4.91 | 45.84 ± 1.99 |
| MCH (pg) | 7.18 ± 0.54 | 7.70 ± 0.78 | 7.66 ± 0.52 | 8.27 ± 0.55 | 7.92 ± 0.51 | 7.08 ± 0.66 |
| MCHC (g/dL) | 15.18 ± 1.04 | 14.88 ± 1.55 | 15.92 ± 1.07 | 16.97 ± 1.69 | 16.06 ± 1.72 | 15.46 ± 0.92 |
| RDW (%) | 31.37 ± 1.10 | 27.64 ± 1.37† | 27.06 ± 2.59† | 31.20 ± 0.57 | 27.32 ± 0.97† | 25.10 ± 2.62† |
| PLT (× 103 cells/μL) | 1240 ± 142.40 | 528 ± 77.91† | 512 ± 88.71† | 1246.7 ± 259.29 | 858 ± 239.93* | 654 ± 274.65* |
| WBC (× 103 cells/μL) | 22.55 ± 8.78 | 20.78 ± 7.81 | 29.82 ± 11.56 | 26.40 ± 7.13 | 25.66 ± 10.15 | 31.06 ± 3.84 |
| Neut (× 103 cells/μL) | 2.63 ± 1.82 | 1.04 ± 0.69 | 1.20 ± 0.72 | 3.2 ± 1.25 | 1.98 ± 1.17 | 1.40 ± 0.73 |
| Lymph (× 103 cells/μL) | 18.53 ± 6.29 | 18.20 ± 6.56 | 26.74 ± 10.44 | 21.33 ± 5.62 | 21.76 ± 8.11 | 26.98 ± 2.06 |
| Mono (× 103 cells/μL) | 0.25 ± 0.17 | 0.30 ± 0.28 | 0.38 ± 0.16 | 0.23 ± 0.15 | 0.34 ± 0.27 | 0.20 ± 0.07 |
| Eos (× 103 cells/μL) | 0.48 ± 0.21 | 0.30 ± 0.14 | 0.32 ± 0.15 | 0.63 ± 0.15 | 0.66 ± 0.34 | 0.42 ± 0.11 |
| . | . | 2 weeks . | . | . | 4 weeks . | . |
|---|---|---|---|---|---|---|
| RN-1 (μg/g) | 0 | 3 | 10 | 0 | 3 | 10 |
| RBC (× 106 cells/μL) | 7.15 ± 1.89 | 7.32 ± 0.69 | 8.02 ± 0.67 | 7.52 ± 0.90 | 7.66 ± 1.09 | 8.00 ± 2.21 |
| HGB (g/dL) | 5.00 ± 1.82 | 5.60 ± 0.89 | 6.00 ± 0.71 | 5.50 ± 0.70 | 6.00 ± 1.22 | 6.33 ± 1.52 |
| HCT (%) | 33.8 ± 8.95 | 38.00 ± 2.91 | 38.80 ± 3.03 | 38.70 ± 9.71 | 37.2 ± 4.32 | 37.5 ± 3.11 |
| MCV (fL) | 47.13 ± 1.72 | 51.92 ± 3.51* | 48.14 ± 0.78 | 48.93 ± 3.79 | 49.84 ± 4.91 | 45.84 ± 1.99 |
| MCH (pg) | 7.18 ± 0.54 | 7.70 ± 0.78 | 7.66 ± 0.52 | 8.27 ± 0.55 | 7.92 ± 0.51 | 7.08 ± 0.66 |
| MCHC (g/dL) | 15.18 ± 1.04 | 14.88 ± 1.55 | 15.92 ± 1.07 | 16.97 ± 1.69 | 16.06 ± 1.72 | 15.46 ± 0.92 |
| RDW (%) | 31.37 ± 1.10 | 27.64 ± 1.37† | 27.06 ± 2.59† | 31.20 ± 0.57 | 27.32 ± 0.97† | 25.10 ± 2.62† |
| PLT (× 103 cells/μL) | 1240 ± 142.40 | 528 ± 77.91† | 512 ± 88.71† | 1246.7 ± 259.29 | 858 ± 239.93* | 654 ± 274.65* |
| WBC (× 103 cells/μL) | 22.55 ± 8.78 | 20.78 ± 7.81 | 29.82 ± 11.56 | 26.40 ± 7.13 | 25.66 ± 10.15 | 31.06 ± 3.84 |
| Neut (× 103 cells/μL) | 2.63 ± 1.82 | 1.04 ± 0.69 | 1.20 ± 0.72 | 3.2 ± 1.25 | 1.98 ± 1.17 | 1.40 ± 0.73 |
| Lymph (× 103 cells/μL) | 18.53 ± 6.29 | 18.20 ± 6.56 | 26.74 ± 10.44 | 21.33 ± 5.62 | 21.76 ± 8.11 | 26.98 ± 2.06 |
| Mono (× 103 cells/μL) | 0.25 ± 0.17 | 0.30 ± 0.28 | 0.38 ± 0.16 | 0.23 ± 0.15 | 0.34 ± 0.27 | 0.20 ± 0.07 |
| Eos (× 103 cells/μL) | 0.48 ± 0.21 | 0.30 ± 0.14 | 0.32 ± 0.15 | 0.63 ± 0.15 | 0.66 ± 0.34 | 0.42 ± 0.11 |
Eos, eosinocyte; HCT, hematocrit; HGB, hemoglobin; Lymph, lymphocyte; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; Mono, monocyte; Neut, neutrophil; PLT, platelet; RBC, red blood cell; RDW, red blood cell distribution width; WBC, white blood cell.
P < .05.
P < .01 vs untreated SCD mice.