Table 2

Univariable and multivariable Fine and Gray competing risk analysis for the development of measurable intracranial hemorrhage

Hazard ratio (90% CI)P value
Univariable regression   
 Age 1.01 (0.99-1.03) .39 
 Enoxaparin 1.02 (0.66-1.59) .93 
 Primary malignancy (Lung cancer as reference)   
 RCC/Melanoma 4.03 (2.56-6.34) <.001 
 Breast cancer/colorectal cancer/Other 0.62 (0.29-1.33) .30 
 Hypertension 0.84 (0.53-1.33) .54 
 Chronic kidney disease 3.19 (1.75-5.85) .002 
 Aspirin use 0.68 (0.32-1.45) .40 
 More than 1 brain met at time of diagnosis 0.99 (0.61-1.59) .97 
 Antiangiogenic agents 0.89 (0.41-1.96) .81 
Multivariable regression   
 Primary malignancy (lung cancer as reference)   
 RCC/melanoma 3.98 (2.41-6.57) <.001 
 Breast cancer/colorectal cancer/Other 0.66 (0.31-1.41) .36 
 Chronic kidney disease 1.62 (0.82-3.16) .24 
Hazard ratio (90% CI)P value
Univariable regression   
 Age 1.01 (0.99-1.03) .39 
 Enoxaparin 1.02 (0.66-1.59) .93 
 Primary malignancy (Lung cancer as reference)   
 RCC/Melanoma 4.03 (2.56-6.34) <.001 
 Breast cancer/colorectal cancer/Other 0.62 (0.29-1.33) .30 
 Hypertension 0.84 (0.53-1.33) .54 
 Chronic kidney disease 3.19 (1.75-5.85) .002 
 Aspirin use 0.68 (0.32-1.45) .40 
 More than 1 brain met at time of diagnosis 0.99 (0.61-1.59) .97 
 Antiangiogenic agents 0.89 (0.41-1.96) .81 
Multivariable regression   
 Primary malignancy (lung cancer as reference)   
 RCC/melanoma 3.98 (2.41-6.57) <.001 
 Breast cancer/colorectal cancer/Other 0.66 (0.31-1.41) .36 
 Chronic kidney disease 1.62 (0.82-3.16) .24 
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