Summary of consensus response criteria adopted at the Sixth International Workshop on WM79
| Response . | Response abbreviation . | Response criteria . |
|---|---|---|
| Complete response | CR | IgM in normal range, and disappearance of monoclonal protein by immunofixation; no histological evidence of bone marrow involvement, and resolution of any adenopathy/organomegaly (if present at baseline), along with no signs or symptoms attributable to WM. Reconfirmation of the CR status is required by repeat immunofixation studies. |
| Very good partial response | VGPR | A ≥90% reduction of serum IgM and decrease in adenopathy/organomegaly (if present at baseline) on physical examination or on CT scan. No new symptoms or signs of active disease. |
| Partial response | PR | A ≥50% reduction of serum IgM and decrease in adenopathy/organomegaly (if present at baseline) on physical examination or on CT scan. No new symptoms or signs of active disease. |
| Minor response | MR | A ≥25% but <50% reduction of serum IgM. No new symptoms or signs of active disease. |
| Stable disease | SD | A <25% reduction and < 25% increase of serum IgM without progression of adenopathy/organomegaly, cytopenias or clinically significant symptoms due to disease and/or signs of WM. |
| Progressive disease | PD | A ≥25% increase in serum IgM by protein confirmed by a second measurement or progression of clinically significant findings due to disease (i.e. anemia, thrombocytopenia, leukopenia, bulky adenopathy/organomegaly) or symptoms (unexplained recurrent fever ≥38.4°C, drenching night sweats, ≥10% body weight loss, or hyperviscosity, neuropathy, symptomatic cryoglobulinemia or amyloidosis) attributable to WM. |
| Response . | Response abbreviation . | Response criteria . |
|---|---|---|
| Complete response | CR | IgM in normal range, and disappearance of monoclonal protein by immunofixation; no histological evidence of bone marrow involvement, and resolution of any adenopathy/organomegaly (if present at baseline), along with no signs or symptoms attributable to WM. Reconfirmation of the CR status is required by repeat immunofixation studies. |
| Very good partial response | VGPR | A ≥90% reduction of serum IgM and decrease in adenopathy/organomegaly (if present at baseline) on physical examination or on CT scan. No new symptoms or signs of active disease. |
| Partial response | PR | A ≥50% reduction of serum IgM and decrease in adenopathy/organomegaly (if present at baseline) on physical examination or on CT scan. No new symptoms or signs of active disease. |
| Minor response | MR | A ≥25% but <50% reduction of serum IgM. No new symptoms or signs of active disease. |
| Stable disease | SD | A <25% reduction and < 25% increase of serum IgM without progression of adenopathy/organomegaly, cytopenias or clinically significant symptoms due to disease and/or signs of WM. |
| Progressive disease | PD | A ≥25% increase in serum IgM by protein confirmed by a second measurement or progression of clinically significant findings due to disease (i.e. anemia, thrombocytopenia, leukopenia, bulky adenopathy/organomegaly) or symptoms (unexplained recurrent fever ≥38.4°C, drenching night sweats, ≥10% body weight loss, or hyperviscosity, neuropathy, symptomatic cryoglobulinemia or amyloidosis) attributable to WM. |