Laboratory and cardiovascular function between groups
| Parameter . | Pretransfusion . | Posttransfusion . | Paired t test P value . | Nontransfused . | Control . |
|---|---|---|---|---|---|
| Laboratory | |||||
| WBC (×103/μL) | 14.0 ± 4.7 | 13.4 ± 4.9 | .22 | 9.5 ± 3.9 | 4.6 ± 1.3 |
| Hematocrit (%) | 28.4 ± 2.6 | 34.2 ± 3.1 | <.0001 | 26.8 ± 4.0 | 40.9 ± 3.1 |
| Hb (g/dL) | 9.5 ± 0.9 | 11.7 ± 1.1 | <.001 | 9.3 ± 1.4 | 13.8 ± 1.2 |
| Platelet (×103/μL) | 321.6 ± 110.0 | 303.7 ± 97.0 | .08 | 385.3 ± 139.3 | 238.4 ± 45.2 |
| HbS (%) | 34.8 ± 18.7 | 29.5 ± 15.7 | <.001 | 78.3 ± 8.5 | 0 |
| RC (×106/μL) | 11.8 ± 6.3 | 8.3 ± 4.8 | <.0001 | 9.3 ± 4.9 | 0.9 ± 0.3 |
| LDH (U/L) | 1196 ± 543 | 1163 ± 536 | .19 | 1134 ± 447 | 484 ± 54 |
| hsCRP (mg/L) | 5.7 ± 5.6 | 4.1 ± 4.3 | .40 | 4.7 ± 3.9 | 0.5 ± 0.8 |
| Arg:Orn | 0.27 ± 0.09 | 0.30 ± 0.15 | .78 | 0.23 ± 0.08 | 0.32 ± 0.05 |
| Plasma free Hb (mg/dL) | 20.7 ± 14.6 | 18.6 ± 13.6 | .71 | 18.7 ± 12.0 | 4.7 ± 2.9 |
| Cardiovascular | |||||
| LV shortening fraction (%) | 38.8 ± 5.5 | 36.9 ± 7.0 | .17 | 37.4 ± 5.2 | 39.2 ± 4.2 |
| Mitral E/A | 2 ± 0.43 | 2.1 ± 0.51 | .04 | 2.2 ± 0.64 | 2.3 ± 0.56 |
| FMD (%) | 5.7 ± 2.8 | 7.2 ± 2.8 | .01 | 5.5 ± 2.5 | 7.9 ± 1.6 |
| TR jet maximum (cm/s) | 219 ± 43 | 215 ± 31 | .51 | 243 ± 31 | 208 ± 12 |
| Cardiac index (L/min per square meter) | 3.3 ± 0.7 | 2.8 ± 0.8 | .004 | 3.6 ± 1.1 | 2.5 ± 0.7 |
| Rheology | |||||
| Viscosity 1 second−1 (n = 16) | 6.4 ± 1.0 | 8.1 ± 1.3 | .0003 | 6.3 ± 1.5 | 9.3 ± 2.3 |
| Viscosity 1000 second−1 (n = 16) | 3.2 ± 0.3 | 3.8 ± 0.4 | .0006 | 3.3 ± 0.5 | 4.0 ± 0.8 |
| Parameter . | Pretransfusion . | Posttransfusion . | Paired t test P value . | Nontransfused . | Control . |
|---|---|---|---|---|---|
| Laboratory | |||||
| WBC (×103/μL) | 14.0 ± 4.7 | 13.4 ± 4.9 | .22 | 9.5 ± 3.9 | 4.6 ± 1.3 |
| Hematocrit (%) | 28.4 ± 2.6 | 34.2 ± 3.1 | <.0001 | 26.8 ± 4.0 | 40.9 ± 3.1 |
| Hb (g/dL) | 9.5 ± 0.9 | 11.7 ± 1.1 | <.001 | 9.3 ± 1.4 | 13.8 ± 1.2 |
| Platelet (×103/μL) | 321.6 ± 110.0 | 303.7 ± 97.0 | .08 | 385.3 ± 139.3 | 238.4 ± 45.2 |
| HbS (%) | 34.8 ± 18.7 | 29.5 ± 15.7 | <.001 | 78.3 ± 8.5 | 0 |
| RC (×106/μL) | 11.8 ± 6.3 | 8.3 ± 4.8 | <.0001 | 9.3 ± 4.9 | 0.9 ± 0.3 |
| LDH (U/L) | 1196 ± 543 | 1163 ± 536 | .19 | 1134 ± 447 | 484 ± 54 |
| hsCRP (mg/L) | 5.7 ± 5.6 | 4.1 ± 4.3 | .40 | 4.7 ± 3.9 | 0.5 ± 0.8 |
| Arg:Orn | 0.27 ± 0.09 | 0.30 ± 0.15 | .78 | 0.23 ± 0.08 | 0.32 ± 0.05 |
| Plasma free Hb (mg/dL) | 20.7 ± 14.6 | 18.6 ± 13.6 | .71 | 18.7 ± 12.0 | 4.7 ± 2.9 |
| Cardiovascular | |||||
| LV shortening fraction (%) | 38.8 ± 5.5 | 36.9 ± 7.0 | .17 | 37.4 ± 5.2 | 39.2 ± 4.2 |
| Mitral E/A | 2 ± 0.43 | 2.1 ± 0.51 | .04 | 2.2 ± 0.64 | 2.3 ± 0.56 |
| FMD (%) | 5.7 ± 2.8 | 7.2 ± 2.8 | .01 | 5.5 ± 2.5 | 7.9 ± 1.6 |
| TR jet maximum (cm/s) | 219 ± 43 | 215 ± 31 | .51 | 243 ± 31 | 208 ± 12 |
| Cardiac index (L/min per square meter) | 3.3 ± 0.7 | 2.8 ± 0.8 | .004 | 3.6 ± 1.1 | 2.5 ± 0.7 |
| Rheology | |||||
| Viscosity 1 second−1 (n = 16) | 6.4 ± 1.0 | 8.1 ± 1.3 | .0003 | 6.3 ± 1.5 | 9.3 ± 2.3 |
| Viscosity 1000 second−1 (n = 16) | 3.2 ± 0.3 | 3.8 ± 0.4 | .0006 | 3.3 ± 0.5 | 4.0 ± 0.8 |
ANOVA for multiple group comparisons was performed to assess differences in hematologic, rheologic, and cardiovascular function parameters. Tukey post hoc comparisons were then performed to determine individual group differences; last, paired Student t tests were performed to evaluate pre- to posttransfusion changes. Values expressed as mean ± standard deviation. ANOVA was significant for almost every parameter (only LV shortening fraction and mitral E/A were not significant); the P value denotes the significance for a paired Student t test (pre- to posttransfusion).
LV, left ventricular; RC, reticulocyte count.