Table 4

Summary of bleeding events (≥2% of patients) regardless of attribution

Bleeding event*, n (%)Any gradeGrade ≥3
Any bleeding 56 (50%) 7 (6%)† 
Contusion 20 (18%) 0 
Epistaxis 12 (11%) 0 
Petechiae 11 (10%) 0 
Hematuria 7 (6%) 2 (2%) 
Ecchymosis 6 (5%) 0 
Increased tendency to bruise 6 (5%) 0 
Purpura 4 (4%) 0 
Subdural hematoma 4 (4%) 2 (2%) 
Traumatic hematoma 3 (3%) 1 (1%) 
Hematospermia 2 (2%) 0 
Bleeding event*, n (%)Any gradeGrade ≥3
Any bleeding 56 (50%) 7 (6%)† 
Contusion 20 (18%) 0 
Epistaxis 12 (11%) 0 
Petechiae 11 (10%) 0 
Hematuria 7 (6%) 2 (2%) 
Ecchymosis 6 (5%) 0 
Increased tendency to bruise 6 (5%) 0 
Purpura 4 (4%) 0 
Subdural hematoma 4 (4%) 2 (2%) 
Traumatic hematoma 3 (3%) 1 (1%) 
Hematospermia 2 (2%) 0 
*

AEs were updated with an estimated median follow-up of 26.7 months.

†

Other grade ≥3 bleeding events were grade 4 splenic and grade 3 lower gastrointestinal hemorrhage, both occurring in the context of disease progression.

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