Prognostic features of transformation
| . | Confirmed transformation . | Confirmed/suspected transformation . | ||||||
|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | χ2P . | HR . | 95% CI . | χ2P . | |||
| Lower . | Upper . | Lower . | Upper . | |||||
| Extranodal sites | .096 | .015 | ||||||
| ≤1 | Ref | Ref | ||||||
| >1 | 1.37 | 0.95 | 1.99 | .096 | 1.39 | 1.07 | 1.81 | .015 |
| Nodal sites | .588 | .167 | ||||||
| <5 | Ref | Ref | ||||||
| ≥5 | 1.10 | 0.78 | 1.55 | .588 | 1.18 | 0.93 | 1.50 | .167 |
| Grade | .175 | .502 | ||||||
| I/II | Ref | Ref | ||||||
| III | 0.94 | 0.60 | 1.49 | .801 | 1.02 | 0.75 | 1.38 | .911 |
| Unknown/missing | 1.52 | 0.96 | 2.43 | .077 | 1.23 | 0.87 | 1.72 | .242 |
| ECOG PS | .117 | <.001 | ||||||
| 0-1 | Ref | Ref | ||||||
| 2+ | 1.74 | 0.79 | 3.85 | .173 | 2.12 | 1.27 | 3.55 | .004 |
| Not done/missing | 1.35 | 0.97 | 1.88 | .079 | 1.62 | 1.30 | 2.03 | <.001 |
| Hb | .274 | .507 | ||||||
| ≥12 g/dL | Ref | Ref | ||||||
| <12 g/dL | 1.32 | 0.91 | 1.93 | .147 | 1.17 | 0.89 | 1.52 | .258 |
| Not done/missing | 0.84 | 0.43 | 1.68 | .626 | 0.97 | 0.63 | 1.50 | .901 |
| LDH | .002 | .003 | ||||||
| Normal | Ref | Ref | ||||||
| >ULN | 2.03 | 1.35 | 3.06 | .001 | 1.57 | 1.17 | 2.10 | .003 |
| Not done/missing | 1.55 | 1.04 | 2.30 | .031 | 1.38 | 1.05 | 1.80 | .020 |
| Stage | .025 | .216 | ||||||
| I/II | Ref | Ref | ||||||
| III/IV | 1.65 | 1.06 | 2.55 | .025 | 1.19 | 0.90 | 1.58 | .216 |
| B Symptoms | .035 | .014 | ||||||
| No | Ref | Ref | ||||||
| Yes | 1.45 | 1.03 | 2.06 | .035 | 1.35 | 1.06 | 1.72 | .014 |
| Age | .043 | .087 | ||||||
| <60 | Ref | Ref | ||||||
| 60-69 | 1.32 | 0.92 | 1.89 | .134 | 1.13 | 0.88 | 1.47 | .343 |
| 70-79 | 1.37 | 0.90 | 2.07 | .141 | 1.41 | 1.06 | 1.88 | .017 |
| 80+ | 0.39 | 0.14 | 1.07 | .068 | 1.41 | 0.93 | 2.13 | .104 |
| . | Confirmed transformation . | Confirmed/suspected transformation . | ||||||
|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | χ2P . | HR . | 95% CI . | χ2P . | |||
| Lower . | Upper . | Lower . | Upper . | |||||
| Extranodal sites | .096 | .015 | ||||||
| ≤1 | Ref | Ref | ||||||
| >1 | 1.37 | 0.95 | 1.99 | .096 | 1.39 | 1.07 | 1.81 | .015 |
| Nodal sites | .588 | .167 | ||||||
| <5 | Ref | Ref | ||||||
| ≥5 | 1.10 | 0.78 | 1.55 | .588 | 1.18 | 0.93 | 1.50 | .167 |
| Grade | .175 | .502 | ||||||
| I/II | Ref | Ref | ||||||
| III | 0.94 | 0.60 | 1.49 | .801 | 1.02 | 0.75 | 1.38 | .911 |
| Unknown/missing | 1.52 | 0.96 | 2.43 | .077 | 1.23 | 0.87 | 1.72 | .242 |
| ECOG PS | .117 | <.001 | ||||||
| 0-1 | Ref | Ref | ||||||
| 2+ | 1.74 | 0.79 | 3.85 | .173 | 2.12 | 1.27 | 3.55 | .004 |
| Not done/missing | 1.35 | 0.97 | 1.88 | .079 | 1.62 | 1.30 | 2.03 | <.001 |
| Hb | .274 | .507 | ||||||
| ≥12 g/dL | Ref | Ref | ||||||
| <12 g/dL | 1.32 | 0.91 | 1.93 | .147 | 1.17 | 0.89 | 1.52 | .258 |
| Not done/missing | 0.84 | 0.43 | 1.68 | .626 | 0.97 | 0.63 | 1.50 | .901 |
| LDH | .002 | .003 | ||||||
| Normal | Ref | Ref | ||||||
| >ULN | 2.03 | 1.35 | 3.06 | .001 | 1.57 | 1.17 | 2.10 | .003 |
| Not done/missing | 1.55 | 1.04 | 2.30 | .031 | 1.38 | 1.05 | 1.80 | .020 |
| Stage | .025 | .216 | ||||||
| I/II | Ref | Ref | ||||||
| III/IV | 1.65 | 1.06 | 2.55 | .025 | 1.19 | 0.90 | 1.58 | .216 |
| B Symptoms | .035 | .014 | ||||||
| No | Ref | Ref | ||||||
| Yes | 1.45 | 1.03 | 2.06 | .035 | 1.35 | 1.06 | 1.72 | .014 |
| Age | .043 | .087 | ||||||
| <60 | Ref | Ref | ||||||
| 60-69 | 1.32 | 0.92 | 1.89 | .134 | 1.13 | 0.88 | 1.47 | .343 |
| 70-79 | 1.37 | 0.90 | 2.07 | .141 | 1.41 | 1.06 | 1.88 | .017 |
| 80+ | 0.39 | 0.14 | 1.07 | .068 | 1.41 | 0.93 | 2.13 | .104 |
Statistical analyses were performed using multivariable Cox regression adjusted for induction treatment.
Bold indicates significant findings, P < .05.
Ref, reference.