Comparison of standard coagulation measurements between controls and FXI-deficient patients divided into nonbleeder and bleeder groups
| Coagulation measures (normal range) . | Controls (n = 50) . | Nonbleeders (n = 50) . | Bleeders (n = 24) . | P nonbleeder vs control . | P bleeder vs control . | P bleeder vs nonbleeder . |
|---|---|---|---|---|---|---|
| PT (12.5-15.3 s) | 13 ± 0.68 | 13.44 ± 0.76 | 13.55 ± 0.76 | ** | ** | ns |
| Fibrinogen (1.82-4.5s) | 2.94 ± 0.51 | 3.42 ± 0.69 | 3.35 ± 0.99 | ** | ns | ns |
| Platelet count (150-400 × 109/L) | 251 ± 47 | 262 ± 69 | 262 ± 62 | ns | ns | ns |
| APTT (24.6-34.9 s) | 29.79 ± 1.8 | 39.4 ± 12.6 | 53.65 ± 29 | **** | **** | ns |
| FXI:C level (60-140 IU/dL) | 104 ± 27.9 | 36.5 ± 16 | 27 ± 18.1 | **** | **** | ns |
| Coagulation measures (normal range) . | Controls (n = 50) . | Nonbleeders (n = 50) . | Bleeders (n = 24) . | P nonbleeder vs control . | P bleeder vs control . | P bleeder vs nonbleeder . |
|---|---|---|---|---|---|---|
| PT (12.5-15.3 s) | 13 ± 0.68 | 13.44 ± 0.76 | 13.55 ± 0.76 | ** | ** | ns |
| Fibrinogen (1.82-4.5s) | 2.94 ± 0.51 | 3.42 ± 0.69 | 3.35 ± 0.99 | ** | ns | ns |
| Platelet count (150-400 × 109/L) | 251 ± 47 | 262 ± 69 | 262 ± 62 | ns | ns | ns |
| APTT (24.6-34.9 s) | 29.79 ± 1.8 | 39.4 ± 12.6 | 53.65 ± 29 | **** | **** | ns |
| FXI:C level (60-140 IU/dL) | 104 ± 27.9 | 36.5 ± 16 | 27 ± 18.1 | **** | **** | ns |
Comparison of results (mean ± SD) between groups was performed using ANOVA test with the Bonferroni multiple comparison test or the Kruskal-Wallis test with Dunn’s multiple comparison test as appropriate to data distribution (**P < .01, ****P < .0001). Note that different mean levels are shown for APTT and FXI:C levels between bleeder and nonbleeder groups. However, as a result of substantial variability in these measurements (indicated by standard deviation), no significant difference was detected by ANOVA analysis, and significant overlap was observed using frequency plots of the measurements.
ns, not significant.