Risk factors for MBL onset and progression to CLL requiring therapy
| Risk factors for MBL onset . | Risk factors for MBL progression to CLL . |
|---|---|
| Family history of CLL | CD38 positivity |
| Genetic polymorphisms* | Unmutated IGHV |
| Age | Deletion 17p |
| Infections† | Elevated B-cell count |
| Risk factors for MBL onset . | Risk factors for MBL progression to CLL . |
|---|---|
| Family history of CLL | CD38 positivity |
| Genetic polymorphisms* | Unmutated IGHV |
| Age | Deletion 17p |
| Infections† | Elevated B-cell count |
More than 20 single-nucleotide polymorphisms associated with the development of CLL have been reported.110 At least 6 of these have also been confirmed as risk factors for MBL (rs17483466, rs13397985, rs757978, rs872071, rs2456449, and rs735665),25 whereas the association of the others with MBL remains under investigation.
Hepatitis C, pneumonia, influenza, cellulitis, upper respiratory infections, and herpes zoster.26-28