Pathological features of the 51 MYC-R DLBCL cases according to the SH/DH or IG/non-IG status
| . | MYC-R (n = 51) . | MYC-SH (n = 19) . | MYC-DH (n = 32) . | . | MYC- IG (n = 24) . | MYC-non-IG (n = 26) . | . |
|---|---|---|---|---|---|---|---|
| . | n (%) . | n (%) . | n (%) . | P (MYC-SH vs MYC-DH) . | n (%) . | n (%) . | P (MYC-IG vs MYC-non-IG) . |
| Histologic subtype | .452 | .221 | |||||
| DLBCL NOS (*) | 47 (92) | 18 (94.7) | 29 (90) | 21 (87.5) | 25 (96.1) | ||
| Consistent with BCLu | 4 (7.8) | 1 (5.3) | 3 (9.4) | 3 (12.5) | 1 (3.8) | ||
| Apoptotic bodies (n = 49) | .0935 | 1.0 | |||||
| 0-2 | 41 (83.7) | 16 (84.2) | 25 (83.3) | 20 (83.3) | 20 (83.3) | ||
| 3 | 8 (16.3) | 3 (15.8) | 5 (16.7) | 4 (16.7) | 4 (16.7) | ||
| Starry sky pattern (n = 49) | .550 | .683 | |||||
| 0-2 | 42 (85.7) | 17 (89.5) | 25 (83.3) | 21 (87.5) | 20 (83.3) | ||
| 3 | 7 (14.3) | 2 (10.5) | 5 (16.7) | 3 (12.5) | 4 (16.7) | ||
| Mitosis (n = 49) | .193 | .745 | |||||
| 0-2 | 36 (73.5) | 12 (63.2) | 24 (80.0) | 18 (75.0) | 17 (70.8) | ||
| 3 | 13 (26.5) | 7 (36.8) | 6 (20.0) | 6 (25.0) | 7 (29.2) | ||
| Hans score (n = 50) | .171 | .682 | |||||
| GCB | 37 (74.0) | 12 (63.2) | 25 (80.6) | 17 (70.8) | 19 (76.0) | ||
| Non-GCB | 13 (26.0) | 7 (36.8) | 6 (19.4) | 7 (29.2) | 6 (24.0) | ||
| Ki67 ≥80% (n = 49) | 30 (61.2) | 15 (78.9) | 15 (50.0) | .043 | 15 (65.2) | 14 (56.0) | .514 |
| BCL2 protein (>50% or 70%) (n = 50) | 37 (74.0) | 11 (57.9) | 26 (83.9) | .042 | 18 (64.3) | 19 (86.4) | .077 |
| MYC protein ≥90% (n = 50) | 23 (46) | 11 (57.9) | 12 (38.7) | .186 | 15 (62.5) | 8 (32) | .032 |
| MYC partner gene† | .038 | <.001 | |||||
| IG (IGH, K, L) | 24 (48) | 12 (63.2) | 12 (38.7) | 24 (100.0) | 0 (0) | ||
| Non-IG | 26 (52) | 7 (36.8) | 19 (61.3) | 0 (0) | 26 (100) |
| . | MYC-R (n = 51) . | MYC-SH (n = 19) . | MYC-DH (n = 32) . | . | MYC- IG (n = 24) . | MYC-non-IG (n = 26) . | . |
|---|---|---|---|---|---|---|---|
| . | n (%) . | n (%) . | n (%) . | P (MYC-SH vs MYC-DH) . | n (%) . | n (%) . | P (MYC-IG vs MYC-non-IG) . |
| Histologic subtype | .452 | .221 | |||||
| DLBCL NOS (*) | 47 (92) | 18 (94.7) | 29 (90) | 21 (87.5) | 25 (96.1) | ||
| Consistent with BCLu | 4 (7.8) | 1 (5.3) | 3 (9.4) | 3 (12.5) | 1 (3.8) | ||
| Apoptotic bodies (n = 49) | .0935 | 1.0 | |||||
| 0-2 | 41 (83.7) | 16 (84.2) | 25 (83.3) | 20 (83.3) | 20 (83.3) | ||
| 3 | 8 (16.3) | 3 (15.8) | 5 (16.7) | 4 (16.7) | 4 (16.7) | ||
| Starry sky pattern (n = 49) | .550 | .683 | |||||
| 0-2 | 42 (85.7) | 17 (89.5) | 25 (83.3) | 21 (87.5) | 20 (83.3) | ||
| 3 | 7 (14.3) | 2 (10.5) | 5 (16.7) | 3 (12.5) | 4 (16.7) | ||
| Mitosis (n = 49) | .193 | .745 | |||||
| 0-2 | 36 (73.5) | 12 (63.2) | 24 (80.0) | 18 (75.0) | 17 (70.8) | ||
| 3 | 13 (26.5) | 7 (36.8) | 6 (20.0) | 6 (25.0) | 7 (29.2) | ||
| Hans score (n = 50) | .171 | .682 | |||||
| GCB | 37 (74.0) | 12 (63.2) | 25 (80.6) | 17 (70.8) | 19 (76.0) | ||
| Non-GCB | 13 (26.0) | 7 (36.8) | 6 (19.4) | 7 (29.2) | 6 (24.0) | ||
| Ki67 ≥80% (n = 49) | 30 (61.2) | 15 (78.9) | 15 (50.0) | .043 | 15 (65.2) | 14 (56.0) | .514 |
| BCL2 protein (>50% or 70%) (n = 50) | 37 (74.0) | 11 (57.9) | 26 (83.9) | .042 | 18 (64.3) | 19 (86.4) | .077 |
| MYC protein ≥90% (n = 50) | 23 (46) | 11 (57.9) | 12 (38.7) | .186 | 15 (62.5) | 8 (32) | .032 |
| MYC partner gene† | .038 | <.001 | |||||
| IG (IGH, K, L) | 24 (48) | 12 (63.2) | 12 (38.7) | 24 (100.0) | 0 (0) | ||
| Non-IG | 26 (52) | 7 (36.8) | 19 (61.3) | 0 (0) | 26 (100) |