Table 2 Results of uni- and... | American Society of Hematology

Table 2

Results of uni- and multivariable analyses in MDS with 1% or more ring sideroblasts and in sideroblastic categories (RARS, RCMD-RS)

Variable	OS			CI of disease progression
	HR	P		HR	P
	HR	Univariable analysis	Multivariable analysis	HR	Univariable analysis	Multivariable analysis
MDS with ≥1% ring sideroblasts
SF3B1 mutation	.26	<.001	.003	.27	.001	.018
Age	1.02	.082	.31	.98	.03	.16
Bone marrow blasts*	1.17	<.001	.001	1.24	<.001	<.001
Multilineage dysplasia†	3.7	<001	.22	2.91	.030	.73
RBC transfusion dependency‡	1.89	.02	.026	1.52	.31	.87
Absolute neutrophil count§	2.96	.015	.46	4.79	.003	.48
Platelet count§	1.76	.006	.61	1.68	.038	.14
Karyotype§	2.28	<.001	.001	1.77	.01	.29
Sideroblastic categories (RARS, RCMD-RS)
SF3B1 mutation	0.25	.001	.007	0.28	.032	.026
Age	1.03	.11	.098	.99	.11	.052
Bone marrow blasts*	1.23	.059	.89	1.18	.33	.51
Multilineage dysplasia†	3.06	.005	.21	2.21	.17	.53
RBC transfusion dependency‡	2.07	.046	.085	1.36	.56	.55
Absolute neutrophil count§	1.19	.86	.77	2.77	.29	.36
Platelet count§	2.20	.011	.51	1.64	.63	.39
Karyotype§	2.11	.029	.069	1.98	.085	.46

Variable	OS			CI of disease progression
	HR	P		HR	P
	HR	Univariable analysis	Multivariable analysis	HR	Univariable analysis	Multivariable analysis
MDS with ≥1% ring sideroblasts
SF3B1 mutation	.26	<.001	.003	.27	.001	.018
Age	1.02	.082	.31	.98	.03	.16
Bone marrow blasts*	1.17	<.001	.001	1.24	<.001	<.001
Multilineage dysplasia†	3.7	<001	.22	2.91	.030	.73
RBC transfusion dependency‡	1.89	.02	.026	1.52	.31	.87
Absolute neutrophil count§	2.96	.015	.46	4.79	.003	.48
Platelet count§	1.76	.006	.61	1.68	.038	.14
Karyotype§	2.28	<.001	.001	1.77	.01	.29
Sideroblastic categories (RARS, RCMD-RS)
SF3B1 mutation	0.25	.001	.007	0.28	.032	.026
Age	1.03	.11	.098	.99	.11	.052
Bone marrow blasts*	1.23	.059	.89	1.18	.33	.51
Multilineage dysplasia†	3.06	.005	.21	2.21	.17	.53
RBC transfusion dependency‡	2.07	.046	.085	1.36	.56	.55
Absolute neutrophil count§	1.19	.86	.77	2.77	.29	.36
Platelet count§	2.20	.011	.51	1.64	.63	.39
Karyotype§	2.11	.029	.069	1.98	.085	.46

Bone marrow blasts were analyzed as a percentage of bone marrow nuclear cells.⁹

†

Multilineage dysplasia was analyzed as uni- vs multilineage dysplasia according to WHO criteria.⁹

‡

RBC transfusion dependency was defined according to Malcovati et al²³ and Such et al.²⁴

Cytogenetic abnormalities, absolute neutrophil count, and platelet count were categorized according to the revised international prognostic scoring system.²⁵

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