Distribution of trisomies and chromosome number according to t(4;14) and del(17p) profiles
| . | Standard risk (n = 633) . | t(4;14) (n = 168) . | χ2P* . | del(17p) (n = 126) . | χ2P† . | χ2P‡ . |
|---|---|---|---|---|---|---|
| Trisomy 3 | 244 (38.5) | 46 (27.4) | .007 | 34 (27.0) | .014 | .867 |
| Trisomy 5 | 306 (48.3) | 15 (8.9) | <.001 | 26 (20.6) | <.001 | .002 |
| Trisomy 7 | 189 (29.9) | 18 (10.7) | <.001 | 23 (18.3) | .008 | .035 |
| Trisomy 9 | 360 (56.9) | 32 (19.0) | <.001 | 40 (31.7) | <.001 | .004 |
| Trisomy 11 | 260 (41.1) | 17 (10.1) | <.001 | 25 (19.8) | <.001 | .009 |
| Trisomy 15 | 336 (53.1) | 45 (26.8) | <.001 | 40 (31.7) | <.001 | .225 |
| Trisomy 17 | 40 (6.3) | 8 (4.8) | .450 | 1 (0.8) | .012 | .061 |
| Trisomy 18 | 83 (13.1) | 7 (4.2) | .001 | 13 (10.3) | .389 | .025 |
| Trisomy 19 | 335 (52.9) | 43 (25.6) | <.001 | 36 (28.6) | <.001 | .396 |
| Trisomy 21 | 177 (28.0) | 17 (10.1) | <.001 | 18 (14.4) | .001 | .190 |
| At least one trisomy | 422 (66.8) | 69 (41.1) | <.001 | 59 (47.2) | <.001 | .123 |
| Number of chromosomes | ||||||
| 46 | 94 (14.8) | 17 (10.1) | 11 (8.7) | |||
| <46 | 157 (24.8) | 102 (60.7) | 71 (56.3) | |||
| 47-50 | 82 (13.0) | 26 (15.5) | 20 (15.9) | |||
| ≥51 | 300 (47.4) | 23 (13.7) | <.001 | 24 (19.0) | <.001 | .468 |
| . | Standard risk (n = 633) . | t(4;14) (n = 168) . | χ2P* . | del(17p) (n = 126) . | χ2P† . | χ2P‡ . |
|---|---|---|---|---|---|---|
| Trisomy 3 | 244 (38.5) | 46 (27.4) | .007 | 34 (27.0) | .014 | .867 |
| Trisomy 5 | 306 (48.3) | 15 (8.9) | <.001 | 26 (20.6) | <.001 | .002 |
| Trisomy 7 | 189 (29.9) | 18 (10.7) | <.001 | 23 (18.3) | .008 | .035 |
| Trisomy 9 | 360 (56.9) | 32 (19.0) | <.001 | 40 (31.7) | <.001 | .004 |
| Trisomy 11 | 260 (41.1) | 17 (10.1) | <.001 | 25 (19.8) | <.001 | .009 |
| Trisomy 15 | 336 (53.1) | 45 (26.8) | <.001 | 40 (31.7) | <.001 | .225 |
| Trisomy 17 | 40 (6.3) | 8 (4.8) | .450 | 1 (0.8) | .012 | .061 |
| Trisomy 18 | 83 (13.1) | 7 (4.2) | .001 | 13 (10.3) | .389 | .025 |
| Trisomy 19 | 335 (52.9) | 43 (25.6) | <.001 | 36 (28.6) | <.001 | .396 |
| Trisomy 21 | 177 (28.0) | 17 (10.1) | <.001 | 18 (14.4) | .001 | .190 |
| At least one trisomy | 422 (66.8) | 69 (41.1) | <.001 | 59 (47.2) | <.001 | .123 |
| Number of chromosomes | ||||||
| 46 | 94 (14.8) | 17 (10.1) | 11 (8.7) | |||
| <46 | 157 (24.8) | 102 (60.7) | 71 (56.3) | |||
| 47-50 | 82 (13.0) | 26 (15.5) | 20 (15.9) | |||
| ≥51 | 300 (47.4) | 23 (13.7) | <.001 | 24 (19.0) | <.001 | .468 |
Comparison between t(4;14) and standard-risk patients.
Comparison between del(17p) and standard-risk patients.
Comparisons between t(4;14) and del(17p) patients; patients with both abnormalities (n = 26) were excluded from this comparison, and 64 patients with missing data on t(4;14) or del(17p) were excluded from this analysis.