Table 3

Summary of current human models for MA4+ B-ALL

Ontogeny stageCell typePhenotypeLeukemic cooperation with FLT3/RAS* mutantsReference
Fetal-HSPC* NA — NA — 
Embryonic HSPC hESC-derived hematopoietic cells Enhances early hemato-endothelial specification No 117  
Skew toward endothelial vs hematopoietic fate 
118  
Neonatal HSPC CB-derived CD34+ HSPCs Proliferation coupled to survival advantage No 116  
Enhanced engraftment and clonogenic potential 
119  
Ontogeny stageCell typePhenotypeLeukemic cooperation with FLT3/RAS* mutantsReference
Fetal-HSPC* NA — NA — 
Embryonic HSPC hESC-derived hematopoietic cells Enhances early hemato-endothelial specification No 117  
Skew toward endothelial vs hematopoietic fate 
118  
Neonatal HSPC CB-derived CD34+ HSPCs Proliferation coupled to survival advantage No 116  
Enhanced engraftment and clonogenic potential 
119  
*

Unpublished preliminary data.

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