Clinical characteristics
| . | MRD responders . | MRD nonresponders . | ||
|---|---|---|---|---|
| OS ≥30 mo (n = 10) . | OS <30 mo (n = 15) . | Total (N = 25) . | OS <30 mo* (N = 11) . | |
| Age, y | ||||
| Median | 35 | 37 | 37 | 27 |
| Range | (21–72) | (23–77) | (21–77) | (18–66) |
| Prior therapy/disease status, n (%) | ||||
| Prior allo-SCT | 4 (40) | 5 (33) | 9 (36) | 6 (55) |
| No prior allo-SCT | 6 (60) | 10 (67) | 16 (64) | 5 (45) |
| Primary refractory | 2 (20) | 0 (0) | 2 (8) | 1 (9) |
| Salvage 1 after first CR | 4 (40) | 6 (40) | 10 (40) | 1 (9) |
| ≤12 mo after initial diagnosis | 2 (20) | 3 (20) | 5 (20) | 0 (0) |
| >12 mo after initial diagnosis | 2 (20) | 3 (20) | 5 (20) | 1 (9) |
| ≥Second salvage | 0 (0) | 4 (27) | 4 (16) | 3 (27) |
| Bone marrow blasts at screening, % | ||||
| Median | 56 | 73 | 61 | 83 |
| Range | (8–97) | (9–93) | (8–97) | (6–96) |
| Prephase treatment, n (%) | ||||
| Dexamethasone | 8 (80) | 6 (40) | 14 (56) | 6 (55) |
| Cyclophosphamide | 4 (40) | 3 (20) | 7 (28) | 5 (46) |
| . | MRD responders . | MRD nonresponders . | ||
|---|---|---|---|---|
| OS ≥30 mo (n = 10) . | OS <30 mo (n = 15) . | Total (N = 25) . | OS <30 mo* (N = 11) . | |
| Age, y | ||||
| Median | 35 | 37 | 37 | 27 |
| Range | (21–72) | (23–77) | (21–77) | (18–66) |
| Prior therapy/disease status, n (%) | ||||
| Prior allo-SCT | 4 (40) | 5 (33) | 9 (36) | 6 (55) |
| No prior allo-SCT | 6 (60) | 10 (67) | 16 (64) | 5 (45) |
| Primary refractory | 2 (20) | 0 (0) | 2 (8) | 1 (9) |
| Salvage 1 after first CR | 4 (40) | 6 (40) | 10 (40) | 1 (9) |
| ≤12 mo after initial diagnosis | 2 (20) | 3 (20) | 5 (20) | 0 (0) |
| >12 mo after initial diagnosis | 2 (20) | 3 (20) | 5 (20) | 1 (9) |
| ≥Second salvage | 0 (0) | 4 (27) | 4 (16) | 3 (27) |
| Bone marrow blasts at screening, % | ||||
| Median | 56 | 73 | 61 | 83 |
| Range | (8–97) | (9–93) | (8–97) | (6–96) |
| Prephase treatment, n (%) | ||||
| Dexamethasone | 8 (80) | 6 (40) | 14 (56) | 6 (55) |
| Cyclophosphamide | 4 (40) | 3 (20) | 7 (28) | 5 (46) |
All of the MRD nonresponders had an OS <30 mo.