Top 46 genes most significantly hypermethylated in promoter regions and downregulated in IDH2 mutant AITL
| Gene . | EntrezID . | Downregulation (IDH2 WT > IDH2 mutant) . | Hypermethylation (IDH2 mutant > normal tissue) . | Correlation between gene expression and methylation . |
|---|---|---|---|---|
| ABL1 | 25 | P = .042 | P = .017 | R = −0.308 |
| AFF1 | 4299 | P = .009 | P = .109 | R = −0.559 |
| AMIGO2 | 347902 | P = .010 | P = .029 | R = −0.704 |
| ANKRD53 | 79998 | P = .006 | P = .065 | R = −0.499 |
| ANTXR2 | 118429 | P = .017 | P = .035 | R = −0.462 |
| APOBR | 55911 | P = .016 | P = .053 | R = −0.449 |
| ATHL1 | 80162 | P = .009 | P = .063 | R = −0.661 |
| ATP8B2 | 57198 | P = .008 | P = .007 | R = −0.301 |
| CD7 | 924 | P = .019 | P = .037 | R = −0.559 |
| CIDEB | 27141 | P = .019 | P = .067 | R = −0.311 |
| CPLX1 | 10815 | P = .048 | P = .001 | R = −0.320 |
| DGKQ | 1609 | P = .004 | P = .079 | R = −0.427 |
| EVC2 | 132884 | P = .037 | P = .045 | R = −0.432 |
| FAM149A | 25854 | P = .035 | P = .024 | R = −0.342 |
| FXYD5 | 53827 | P = .046 | P = .002 | R = −0.400 |
| FZD6 | 8323 | P = .049 | P = .005 | R = −0.411 |
| GIMAP8 | 155038 | P = .008 | P = .021 | R = −0.392 |
| GPR68 | 8111 | P = .049 | P = .064 | R = −0.439 |
| HDAC11 | 79885 | P = .037 | P = .010 | R = −0.462 |
| HKR1 | 284459 | P = .024 | P = .067 | R = −0.533 |
| IL10RA | 3587 | P = .001 | P = .014 | R = −0.451 |
| ISYNA1 | 51477 | P = .018 | P = .025 | R = −0.602 |
| KBTBD11 | 9920 | P = .024 | P = .002 | R = −0.402 |
| KCNJ4 | 3761 | P = .032 | P < .001 | R = −0.490 |
| KLF3 | 51274 | P = .008 | P = .018 | R = −0.634 |
| KLHL22 | 84861 | P = .004 | P = .008 | R = −0.534 |
| LPAR2 | 9170 | P = .005 | P = .034 | R = −0.427 |
| NOVA2 | 4858 | P = .025 | P = .013 | R = −0.341 |
| NTN1 | 9423 | P = .047 | P = .266 | R = −0.309 |
| PDLIM2 | 64236 | P = .001 | P = .005 | R = −0.385 |
| PTGDR | 5729 | P = .044 | P = .016 | R = −0.320 |
| PTPN3 | 5774 | P = .042 | P < .001 | R = −0.321 |
| SATB1 | 6304 | P = .013 | P = .087 | R = −0.555 |
| SECTM1 | 6398 | P = .002 | P = .083 | R = −0.444 |
| SLC12A7 | 10723 | P = .009 | P = .006 | R = −0.572 |
| SLC1A6 | 6511 | P = .043 | P = .117 | R = −0.426 |
| SLC35D2 | 11046 | P = .002 | P = .019 | R = −0.380 |
| SMAD7 | 4092 | P = .025 | P = .009 | R = −0.335 |
| SMO | 6608 | P = .015 | P = .004 | R = −0.300 |
| SMURF2 | 64750 | P = .006 | P = .003 | R = −0.378 |
| SPNS2 | 124976 | P = .045 | P = .018 | R = −0.338 |
| TCEA3 | 6920 | P = .004 | P = .029 | R = −0.462 |
| XKR8 | 55113 | P = .012 | P < .001 | R = −0.666 |
| ZBTB4 | 57659 | P = .001 | P = .001 | R = −0.774 |
| ZFP3 | 124961 | P = .012 | P = .003 | R = −0.357 |
| ZNF704 | 619279 | P = .024 | P = .059 | R = −0.363 |
| Gene . | EntrezID . | Downregulation (IDH2 WT > IDH2 mutant) . | Hypermethylation (IDH2 mutant > normal tissue) . | Correlation between gene expression and methylation . |
|---|---|---|---|---|
| ABL1 | 25 | P = .042 | P = .017 | R = −0.308 |
| AFF1 | 4299 | P = .009 | P = .109 | R = −0.559 |
| AMIGO2 | 347902 | P = .010 | P = .029 | R = −0.704 |
| ANKRD53 | 79998 | P = .006 | P = .065 | R = −0.499 |
| ANTXR2 | 118429 | P = .017 | P = .035 | R = −0.462 |
| APOBR | 55911 | P = .016 | P = .053 | R = −0.449 |
| ATHL1 | 80162 | P = .009 | P = .063 | R = −0.661 |
| ATP8B2 | 57198 | P = .008 | P = .007 | R = −0.301 |
| CD7 | 924 | P = .019 | P = .037 | R = −0.559 |
| CIDEB | 27141 | P = .019 | P = .067 | R = −0.311 |
| CPLX1 | 10815 | P = .048 | P = .001 | R = −0.320 |
| DGKQ | 1609 | P = .004 | P = .079 | R = −0.427 |
| EVC2 | 132884 | P = .037 | P = .045 | R = −0.432 |
| FAM149A | 25854 | P = .035 | P = .024 | R = −0.342 |
| FXYD5 | 53827 | P = .046 | P = .002 | R = −0.400 |
| FZD6 | 8323 | P = .049 | P = .005 | R = −0.411 |
| GIMAP8 | 155038 | P = .008 | P = .021 | R = −0.392 |
| GPR68 | 8111 | P = .049 | P = .064 | R = −0.439 |
| HDAC11 | 79885 | P = .037 | P = .010 | R = −0.462 |
| HKR1 | 284459 | P = .024 | P = .067 | R = −0.533 |
| IL10RA | 3587 | P = .001 | P = .014 | R = −0.451 |
| ISYNA1 | 51477 | P = .018 | P = .025 | R = −0.602 |
| KBTBD11 | 9920 | P = .024 | P = .002 | R = −0.402 |
| KCNJ4 | 3761 | P = .032 | P < .001 | R = −0.490 |
| KLF3 | 51274 | P = .008 | P = .018 | R = −0.634 |
| KLHL22 | 84861 | P = .004 | P = .008 | R = −0.534 |
| LPAR2 | 9170 | P = .005 | P = .034 | R = −0.427 |
| NOVA2 | 4858 | P = .025 | P = .013 | R = −0.341 |
| NTN1 | 9423 | P = .047 | P = .266 | R = −0.309 |
| PDLIM2 | 64236 | P = .001 | P = .005 | R = −0.385 |
| PTGDR | 5729 | P = .044 | P = .016 | R = −0.320 |
| PTPN3 | 5774 | P = .042 | P < .001 | R = −0.321 |
| SATB1 | 6304 | P = .013 | P = .087 | R = −0.555 |
| SECTM1 | 6398 | P = .002 | P = .083 | R = −0.444 |
| SLC12A7 | 10723 | P = .009 | P = .006 | R = −0.572 |
| SLC1A6 | 6511 | P = .043 | P = .117 | R = −0.426 |
| SLC35D2 | 11046 | P = .002 | P = .019 | R = −0.380 |
| SMAD7 | 4092 | P = .025 | P = .009 | R = −0.335 |
| SMO | 6608 | P = .015 | P = .004 | R = −0.300 |
| SMURF2 | 64750 | P = .006 | P = .003 | R = −0.378 |
| SPNS2 | 124976 | P = .045 | P = .018 | R = −0.338 |
| TCEA3 | 6920 | P = .004 | P = .029 | R = −0.462 |
| XKR8 | 55113 | P = .012 | P < .001 | R = −0.666 |
| ZBTB4 | 57659 | P = .001 | P = .001 | R = −0.774 |
| ZFP3 | 124961 | P = .012 | P = .003 | R = −0.357 |
| ZNF704 | 619279 | P = .024 | P = .059 | R = −0.363 |