Table 4 Prediction of iron absorption... | American Society of Hematology

Table 4

Prediction of iron absorption from the first and second dose of iron supplements, depending on the time point of PHep and BIS

	Dependent variable
	First dose fractional absorption (%), n=40			Second dose fractional absorption, %, n=40
	Independent variables, standardized β			Independent variables, standardized β
Model R²	Dose (mg)	BIS mg/kg BW	Log hepcidin (nM)	Model R²	Dose (mg)	BIS mg/kg BW, preceding day	BIS at administration mg/kg BW	Log hepcidin (nM), preceding day	Log hepcidin (nM), at administration	Hepcidin increase on previous day
0.650*	−0.397†	−0.585‡	n.s.	0.791§	−0.480‡	—	−0.447‡	−0.330†	—	—
0.642*	−.394†	−0.628‡	—	0.780§	−0.463‡	−0.535‡	—	−0.535†	—	—
0.391‡	−0.509†	—	−0.376†	0.768§	−0.419‡	—	−0.461‡	—	—	−0.283†
0.248‡	−0.498†	—	—	0.727§	−0.365†	−0.590²	—	—	n.s.	—
				0.719§	−0.405‡	—	−0.565‡	—	n.s.	—
				0.706§	−0.407‡	−0.664‡	—	—	—	—
				0.557‖	−.550‡	—	—	−0.519‡	—	—
				0.476¶	−0.391†	—	—	—	−0.452†	—
				0.476¶	−0.463†	—	—	—	—	−0.421†

	Dependent variable
	First dose fractional absorption (%), n=40			Second dose fractional absorption, %, n=40
	Independent variables, standardized β			Independent variables, standardized β
Model R²	Dose (mg)	BIS mg/kg BW	Log hepcidin (nM)	Model R²	Dose (mg)	BIS mg/kg BW, preceding day	BIS at administration mg/kg BW	Log hepcidin (nM), preceding day	Log hepcidin (nM), at administration	Hepcidin increase on previous day
0.650*	−0.397†	−0.585‡	n.s.	0.791§	−0.480‡	—	−0.447‡	−0.330†	—	—
0.642*	−.394†	−0.628‡	—	0.780§	−0.463‡	−0.535‡	—	−0.535†	—	—
0.391‡	−0.509†	—	−0.376†	0.768§	−0.419‡	—	−0.461‡	—	—	−0.283†
0.248‡	−0.498†	—	—	0.727§	−0.365†	−0.590²	—	—	n.s.	—
				0.719§	−0.405‡	—	−0.565‡	—	n.s.	—
				0.706§	−0.407‡	−0.664‡	—	—	—	—
				0.557‖	−.550‡	—	—	−0.519‡	—	—
				0.476¶	−0.391†	—	—	—	−0.452†	—
				0.476¶	−0.463†	—	—	—	—	−0.421†

n.s., nonsignificant parameter in the model.

Differences between nested models were tested with change in F statistic; differences between non-nested models were tested by comparing different R coefficients with the Steiger Z test. Reported models differ significantly if superscript differs, P < .01.

All models are significant at P < .01.

Different from models ‡, P < .01.

†

Significant regression parameter P < .05.

‡

Significant regression parameter P < .001.

Different from all other models, P < .01.

‖

Different from all other models; P < .01.

Different from all other models, P < .01.

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