Clinical and baseline characteristics
| Characteristic . | All patients . | ΔNp73/TAp73 ratio . | P . | |
|---|---|---|---|---|
| Low expression . | High expression . | |||
| Sex, no. (%) | .07 | |||
| Female | 69 (53.5) | 56 (58.3) | 13 (39.4) | |
| Male | 60 (46.5) | 40 (41.7) | 20 (60.6) | |
| Age, median (range), y | 34 (9, 73) | 34 (16, 73) | 31 (9, 60) | .75 |
| ECOG performance status, no. (%) | .12 | |||
| 0 | 81 (62.8) | 64 (66.7) | 17 (51.5) | |
| 1 | 22 (17.1) | 16 (16.7) | 6 (18.2) | |
| 2 | 15 (11.6) | 11 (11.5) | 4 (12.1) | |
| ≥3 | 11 (8.5) | 5 (5.2) | 6 (18.2) | |
| Relapse-risk group, no. (%) | <.0001 | |||
| High | 45 (34.9) | 23 (24) | 22 (66.7) | |
| Intermediate | 61 (47.3) | 51 (53.1) | 10 (30.3) | |
| Low | 23 (17.8) | 22 (22.9) | 1 (3) | |
| Morphologic subtype, no. (%) | .37 | |||
| Hypergranular | 122 (94.6) | 92 (95.8) | 30 (90.9) | |
| Microgranular | 7 (5.4) | 4 (4.2) | 3 (9.1) | |
| PML breakpoint, no. (%) | .24 | |||
| BCR1 | 70 (54.3) | 54 (56.3) | 16 (48.5) | |
| BCR2 | 3 (2.3) | 3 (3.1) | — | |
| BCR3 | 44 (34.1) | 29 (30.2) | 15 (45.5) | |
| Unknown | 12 (9.3) | 10 (10.4) | 2 (6.1) | |
| Fever, no. (%) | .31 | |||
| No | 66 (51.2) | 52 (54.2) | 14 (42.4) | |
| Yes | 63 (48.8) | 44 (45.8) | 19 (57.6) | |
| WBC counts, no. (%), ×109/L | .0002 | |||
| ≤5 | 68 (52.7) | 59 (61.5) | 9 (27.3) | |
| 5-10 | 16 (12.4) | 14 (14.6) | 2 (6.1) | |
| 10-50 | 32 (24.8) | 17 (17.7) | 15 (45.5) | |
| >50 | 13 (1.1) | 6 (6.3) | 7 (21.2) | |
| Median (range) | 4.3 (0.2, 13.2) | 2.9 (0.2, 102.7) | 23.7 (0.5, 132.5) | |
| Platelet counts, no. (%), ×109/L | .49 | |||
| ≤40 | 96 (74.4) | 73 (76) | 23 (69.7) | |
| >40 | 33 (25.6) | 23 (24) | 10 (30.3) | |
| Median (range) | 27 (3, 128) | 27 (4, 128) | 30 (3, 99) | |
| Hemoglobin, no. (%), g/dL | .15 | |||
| ≤10 | 99 (76.7) | 77 (80.2) | 22 (66.7) | |
| >10 | 30 (23.3) | 19 (19.8) | 11 (33.3) | |
| Median (range) | 8.7 (3.4, 14.1) | 8.7 (4.4, 14.1) | 9.5 (3.4, 12.5) | |
| Creatinine, no. (%), mg/dL | .65 | |||
| ≤1.4 | 123 (95.3) | 92 (95.8) | 31 (93.9) | |
| >1.4 | 6 (4.7) | 4 (4.2) | 2 (6.1) | |
| Median (range) | 0.8 (0.3, 4.3) | 0.8 (0.3, 4.3) | 0.9 (0.4, 1.9) | |
| Uric acid, no. (%), mg/dL | .32 | |||
| ≤7 | 114 (88.4) | 82 (85.4) | 32 (97) | |
| >7 | 5 (3.9) | 5 (5.2) | — | |
| Unknown | 10 (7.8) | 9 (9.4) | 1 (3) | |
| Median (range) | 3.7 (0.8, 9.2) | 3.6 (0.8, 9.2) | 4.2 (2.1, 6.6) | |
| Fibrinogen, no. (%), mg/dL | .68 | |||
| ≤170 | 70 (54.3) | 51 (53.1) | 19 (57.6) | |
| >170 | 54 (41.9) | 42 (43.8) | 12 (36.4) | |
| Unknown | 5 (3.9) | 3 (3.1) | 2 (6.1) | |
| Median (range) | 159.5 (10, 605) | 160 (10, 605) | 159 (52.0, 373.0) | |
| Albumin, no. (%), g/dL | .39 | |||
| ≤3.5 | 19 (14.7) | 12 (12.5) | 7 (21.2) | |
| >3.5 | 81 (62.8) | 61 (63.5) | 20 (60.6) | |
| Unknown | 29 (22.5) | 23 (24) | 6 (18.2) | |
| Median (range) | 4 (2.2, 5.4) | 4.1 (2.2, 5.4) | 3.9 (2.3, 5.2) | |
| Coagulopathy, no. (%) | .70 | |||
| No | 47 (36.4) | 35 (36.5) | 12 (36.4) | |
| Yes | 80 (62) | 59 (61.5) | 21 (63.6) | |
| CR, % | 85 | 89 | 76 | .09 |
| 3-y OS, % (95% CI) | 84 (77, 90) | 91 (83, 95) | 67 (48, 80) | .0005 |
| 3-y DFS, % (95% CI) | 87 (78, 92) | 95 (88, 98) | 62 (39, 78) | <.0001 |
| 3-y CIR, % (95% CI) | 9 (4, 16) | 1.2 (0.1, 6) | 30 (13, 49) | <.0001 |
| 3-y CI of NRM, % (95% CI) | 4.6 (2, 10) | 3.5 (1, 9) | 8 (1.3, 23) | .36 |
| Characteristic . | All patients . | ΔNp73/TAp73 ratio . | P . | |
|---|---|---|---|---|
| Low expression . | High expression . | |||
| Sex, no. (%) | .07 | |||
| Female | 69 (53.5) | 56 (58.3) | 13 (39.4) | |
| Male | 60 (46.5) | 40 (41.7) | 20 (60.6) | |
| Age, median (range), y | 34 (9, 73) | 34 (16, 73) | 31 (9, 60) | .75 |
| ECOG performance status, no. (%) | .12 | |||
| 0 | 81 (62.8) | 64 (66.7) | 17 (51.5) | |
| 1 | 22 (17.1) | 16 (16.7) | 6 (18.2) | |
| 2 | 15 (11.6) | 11 (11.5) | 4 (12.1) | |
| ≥3 | 11 (8.5) | 5 (5.2) | 6 (18.2) | |
| Relapse-risk group, no. (%) | <.0001 | |||
| High | 45 (34.9) | 23 (24) | 22 (66.7) | |
| Intermediate | 61 (47.3) | 51 (53.1) | 10 (30.3) | |
| Low | 23 (17.8) | 22 (22.9) | 1 (3) | |
| Morphologic subtype, no. (%) | .37 | |||
| Hypergranular | 122 (94.6) | 92 (95.8) | 30 (90.9) | |
| Microgranular | 7 (5.4) | 4 (4.2) | 3 (9.1) | |
| PML breakpoint, no. (%) | .24 | |||
| BCR1 | 70 (54.3) | 54 (56.3) | 16 (48.5) | |
| BCR2 | 3 (2.3) | 3 (3.1) | — | |
| BCR3 | 44 (34.1) | 29 (30.2) | 15 (45.5) | |
| Unknown | 12 (9.3) | 10 (10.4) | 2 (6.1) | |
| Fever, no. (%) | .31 | |||
| No | 66 (51.2) | 52 (54.2) | 14 (42.4) | |
| Yes | 63 (48.8) | 44 (45.8) | 19 (57.6) | |
| WBC counts, no. (%), ×109/L | .0002 | |||
| ≤5 | 68 (52.7) | 59 (61.5) | 9 (27.3) | |
| 5-10 | 16 (12.4) | 14 (14.6) | 2 (6.1) | |
| 10-50 | 32 (24.8) | 17 (17.7) | 15 (45.5) | |
| >50 | 13 (1.1) | 6 (6.3) | 7 (21.2) | |
| Median (range) | 4.3 (0.2, 13.2) | 2.9 (0.2, 102.7) | 23.7 (0.5, 132.5) | |
| Platelet counts, no. (%), ×109/L | .49 | |||
| ≤40 | 96 (74.4) | 73 (76) | 23 (69.7) | |
| >40 | 33 (25.6) | 23 (24) | 10 (30.3) | |
| Median (range) | 27 (3, 128) | 27 (4, 128) | 30 (3, 99) | |
| Hemoglobin, no. (%), g/dL | .15 | |||
| ≤10 | 99 (76.7) | 77 (80.2) | 22 (66.7) | |
| >10 | 30 (23.3) | 19 (19.8) | 11 (33.3) | |
| Median (range) | 8.7 (3.4, 14.1) | 8.7 (4.4, 14.1) | 9.5 (3.4, 12.5) | |
| Creatinine, no. (%), mg/dL | .65 | |||
| ≤1.4 | 123 (95.3) | 92 (95.8) | 31 (93.9) | |
| >1.4 | 6 (4.7) | 4 (4.2) | 2 (6.1) | |
| Median (range) | 0.8 (0.3, 4.3) | 0.8 (0.3, 4.3) | 0.9 (0.4, 1.9) | |
| Uric acid, no. (%), mg/dL | .32 | |||
| ≤7 | 114 (88.4) | 82 (85.4) | 32 (97) | |
| >7 | 5 (3.9) | 5 (5.2) | — | |
| Unknown | 10 (7.8) | 9 (9.4) | 1 (3) | |
| Median (range) | 3.7 (0.8, 9.2) | 3.6 (0.8, 9.2) | 4.2 (2.1, 6.6) | |
| Fibrinogen, no. (%), mg/dL | .68 | |||
| ≤170 | 70 (54.3) | 51 (53.1) | 19 (57.6) | |
| >170 | 54 (41.9) | 42 (43.8) | 12 (36.4) | |
| Unknown | 5 (3.9) | 3 (3.1) | 2 (6.1) | |
| Median (range) | 159.5 (10, 605) | 160 (10, 605) | 159 (52.0, 373.0) | |
| Albumin, no. (%), g/dL | .39 | |||
| ≤3.5 | 19 (14.7) | 12 (12.5) | 7 (21.2) | |
| >3.5 | 81 (62.8) | 61 (63.5) | 20 (60.6) | |
| Unknown | 29 (22.5) | 23 (24) | 6 (18.2) | |
| Median (range) | 4 (2.2, 5.4) | 4.1 (2.2, 5.4) | 3.9 (2.3, 5.2) | |
| Coagulopathy, no. (%) | .70 | |||
| No | 47 (36.4) | 35 (36.5) | 12 (36.4) | |
| Yes | 80 (62) | 59 (61.5) | 21 (63.6) | |
| CR, % | 85 | 89 | 76 | .09 |
| 3-y OS, % (95% CI) | 84 (77, 90) | 91 (83, 95) | 67 (48, 80) | .0005 |
| 3-y DFS, % (95% CI) | 87 (78, 92) | 95 (88, 98) | 62 (39, 78) | <.0001 |
| 3-y CIR, % (95% CI) | 9 (4, 16) | 1.2 (0.1, 6) | 30 (13, 49) | <.0001 |
| 3-y CI of NRM, % (95% CI) | 4.6 (2, 10) | 3.5 (1, 9) | 8 (1.3, 23) | .36 |
CI, cumulative incidence; CIR, cumulative incidence of relapse; CR, complete remission; NRM, nonrelapse mortality.