Table 2

SIR of HL in first-degree relatives of HL patients by age at diagnosis in 5 Nordic countries

Age at diagnosis (y)HL patient in family
One first-degree relativeTwo or more first-degree relativesSame-sex twin
SiblingParent/child
PatientRelativeNo.SIR95% CINo.SIR95% CINo.SIR95% CINo.SIR95% CI
All All 87 6.0 4.8-7.4 62 2.1 1.6-2.6 13 2.8-39 57 21-125 
 <30 50 5.8 4.3-7.7 23 3.2 2.0-4.8 41 8.4-119 63 17-161 
 30-59 34 6.3 4.4-8.8 34 2.1 1.5-3.0   26 0.7-146 
 ≥60 5.0 1.0-15 0.7 0.2-1.7   325 8.2-1812 
<30 All 49 6.3 4.7-8.4 31 2.5 1.7-3.5 49 10-142 66 18-168 
 <30 34 6.5 4.5-9.0 11 5.1 2.5-9.1 158 33-461 93 25-239 
 30-59 14 5.8* 3.2-9.8 20 2.6 1.6-4.0     
30-59 All 36 5.9 4.1-8.1 27 2.2 1.4-3.1   26 0.7-143 
 <30 16 5.1 2.9-8.2 12 3.4 1.8-6.0     
 30-59 19 7.1 4.3-11 12 2.1 1.1-3.7     
 ≥60 3.5 0.1-20 0.9 0.2-2.7   1107 28-6166 
≥60 All 3.0 0.4-11 0.8 0.2-2.0   202 5.1-1123 
Age at diagnosis (y)HL patient in family
One first-degree relativeTwo or more first-degree relativesSame-sex twin
SiblingParent/child
PatientRelativeNo.SIR95% CINo.SIR95% CINo.SIR95% CINo.SIR95% CI
All All 87 6.0 4.8-7.4 62 2.1 1.6-2.6 13 2.8-39 57 21-125 
 <30 50 5.8 4.3-7.7 23 3.2 2.0-4.8 41 8.4-119 63 17-161 
 30-59 34 6.3 4.4-8.8 34 2.1 1.5-3.0   26 0.7-146 
 ≥60 5.0 1.0-15 0.7 0.2-1.7   325 8.2-1812 
<30 All 49 6.3 4.7-8.4 31 2.5 1.7-3.5 49 10-142 66 18-168 
 <30 34 6.5 4.5-9.0 11 5.1 2.5-9.1 158 33-461 93 25-239 
 30-59 14 5.8* 3.2-9.8 20 2.6 1.6-4.0     
30-59 All 36 5.9 4.1-8.1 27 2.2 1.4-3.1   26 0.7-143 
 <30 16 5.1 2.9-8.2 12 3.4 1.8-6.0     
 30-59 19 7.1 4.3-11 12 2.1 1.1-3.7     
 ≥60 3.5 0.1-20 0.9 0.2-2.7   1107 28-6166 
≥60 All 3.0 0.4-11 0.8 0.2-2.0   202 5.1-1123 
*

Example: Risk of HL in a 40-year-old person with a family history of early-onset HL (before age 30 years) in his/her sibling was 5.8-fold higher than the risk in his/her counterpart in the general population. Only those rows with a significant age-specific SIR in them are presented.

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