SIR of HL in first-degree relatives of HL patients by age at diagnosis in 5 Nordic countries
Age at diagnosis (y) . | HL patient in family . | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
One first-degree relative . | Two or more first-degree relatives . | Same-sex twin . | |||||||||||
Sibling . | Parent/child . | ||||||||||||
Patient . | Relative . | No. . | SIR . | 95% CI . | No. . | SIR . | 95% CI . | No. . | SIR . | 95% CI . | No. . | SIR . | 95% CI . |
All | All | 87 | 6.0 | 4.8-7.4 | 62 | 2.1 | 1.6-2.6 | 3 | 13 | 2.8-39 | 6 | 57 | 21-125 |
<30 | 50 | 5.8 | 4.3-7.7 | 23 | 3.2 | 2.0-4.8 | 3 | 41 | 8.4-119 | 4 | 63 | 17-161 | |
30-59 | 34 | 6.3 | 4.4-8.8 | 34 | 2.1 | 1.5-3.0 | 0 | 1 | 26 | 0.7-146 | |||
≥60 | 3 | 5.0 | 1.0-15 | 5 | 0.7 | 0.2-1.7 | 0 | 1 | 325 | 8.2-1812 | |||
<30 | All | 49 | 6.3 | 4.7-8.4 | 31 | 2.5 | 1.7-3.5 | 3 | 49 | 10-142 | 4 | 66 | 18-168 |
<30 | 34 | 6.5 | 4.5-9.0 | 11 | 5.1 | 2.5-9.1 | 3 | 158 | 33-461 | 4 | 93 | 25-239 | |
30-59 | 14 | 5.8* | 3.2-9.8 | 20 | 2.6 | 1.6-4.0 | 0 | 0 | |||||
30-59 | All | 36 | 5.9 | 4.1-8.1 | 27 | 2.2 | 1.4-3.1 | 0 | 1 | 26 | 0.7-143 | ||
<30 | 16 | 5.1 | 2.9-8.2 | 12 | 3.4 | 1.8-6.0 | 0 | 0 | |||||
30-59 | 19 | 7.1 | 4.3-11 | 12 | 2.1 | 1.1-3.7 | 0 | 0 | |||||
≥60 | 1 | 3.5 | 0.1-20 | 3 | 0.9 | 0.2-2.7 | 0 | 1 | 1107 | 28-6166 | |||
≥60 | All | 2 | 3.0 | 0.4-11 | 4 | 0.8 | 0.2-2.0 | 0 | 1 | 202 | 5.1-1123 |
Age at diagnosis (y) . | HL patient in family . | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
One first-degree relative . | Two or more first-degree relatives . | Same-sex twin . | |||||||||||
Sibling . | Parent/child . | ||||||||||||
Patient . | Relative . | No. . | SIR . | 95% CI . | No. . | SIR . | 95% CI . | No. . | SIR . | 95% CI . | No. . | SIR . | 95% CI . |
All | All | 87 | 6.0 | 4.8-7.4 | 62 | 2.1 | 1.6-2.6 | 3 | 13 | 2.8-39 | 6 | 57 | 21-125 |
<30 | 50 | 5.8 | 4.3-7.7 | 23 | 3.2 | 2.0-4.8 | 3 | 41 | 8.4-119 | 4 | 63 | 17-161 | |
30-59 | 34 | 6.3 | 4.4-8.8 | 34 | 2.1 | 1.5-3.0 | 0 | 1 | 26 | 0.7-146 | |||
≥60 | 3 | 5.0 | 1.0-15 | 5 | 0.7 | 0.2-1.7 | 0 | 1 | 325 | 8.2-1812 | |||
<30 | All | 49 | 6.3 | 4.7-8.4 | 31 | 2.5 | 1.7-3.5 | 3 | 49 | 10-142 | 4 | 66 | 18-168 |
<30 | 34 | 6.5 | 4.5-9.0 | 11 | 5.1 | 2.5-9.1 | 3 | 158 | 33-461 | 4 | 93 | 25-239 | |
30-59 | 14 | 5.8* | 3.2-9.8 | 20 | 2.6 | 1.6-4.0 | 0 | 0 | |||||
30-59 | All | 36 | 5.9 | 4.1-8.1 | 27 | 2.2 | 1.4-3.1 | 0 | 1 | 26 | 0.7-143 | ||
<30 | 16 | 5.1 | 2.9-8.2 | 12 | 3.4 | 1.8-6.0 | 0 | 0 | |||||
30-59 | 19 | 7.1 | 4.3-11 | 12 | 2.1 | 1.1-3.7 | 0 | 0 | |||||
≥60 | 1 | 3.5 | 0.1-20 | 3 | 0.9 | 0.2-2.7 | 0 | 1 | 1107 | 28-6166 | |||
≥60 | All | 2 | 3.0 | 0.4-11 | 4 | 0.8 | 0.2-2.0 | 0 | 1 | 202 | 5.1-1123 |
Example: Risk of HL in a 40-year-old person with a family history of early-onset HL (before age 30 years) in his/her sibling was 5.8-fold higher than the risk in his/her counterpart in the general population. Only those rows with a significant age-specific SIR in them are presented.