Univariate and multivariate analysis of PFS
| . | . | . | . | . | . | . | . | . | Internal bootstrapping validation . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Univariate analysis . | Multivariate analysis . | Bootstrap parameters (mean) . | |||||||||
| Characteristics . | 5-y PFS (%) . | Median PFS . | 95% CI . | P . | HR . | LCI . | UCI . | P . | HR . | LCI . | UCI . | Bootstrap selection (%) . |
| Age <65 y | 46.6 | 58.1 | 49.5-66.6 | .0617 | — | — | — | .2323 | — | — | — | 39.40 |
| Age ≥65 y | 42.9 | 46.5 | 36.0-56.9 | 1.23 | 0.87 | 1.75 | 1.24 | 0.87 | 1.78 | |||
| Binet A | 59.5 | 64.7 | 31.8-96.6 | .0848 | — | — | — | .1474 | — | — | — | 55.90 |
| Binet B+C | 43.5 | 54.3 | 48.3-60.3 | 1.57 | 0.85 | 2.91 | 1.72 | 0.88 | 3.4 | |||
| IGHV mutated | 58.6 | nr | na | .0005 | — | — | — | .0099 | — | — | — | 88.00 |
| IGHV unnmutated | 36.3 | 48.2 | 43.7-52.7 | 1.65 | 1.12 | 2.41 | 1.7 | 1.15 | 2.52 | |||
| No 11q deletion | 49.4 | 56.9 | 47.1-66.6 | .0106 | — | — | — | .0096 | — | — | — | 88.90 |
| 11q deletion | 18.4 | 43.5 | 32.2-54.7 | 1.67 | 1.13 | 2.46 | 1.67 | 1.16 | 2.56 | |||
| No 17p deletion | 48 | 58.9 | 49.3-68.4 | <.0001 | — | — | — | <.0001 | — | — | — | 100 |
| 17p deletion | 10.9 | 22.5 | 8.5-36.4 | 3.72 | 2.42 | 5.71 | 4.04 | 2.59 | 6.31 | |||
| Female | 50.1 | 66.2 | 50.5-82.0 | .324 | — | — | — | — | — | — | — | — |
| Male | 42.7 | 51.6 | 43.8-59.3 | — | — | — | — | — | — | |||
| No13q deletion | 45.4 | 55.6 | 48.3-62.8 | .9041 | — | — | — | — | — | — | — | — |
| 13q deletion | 41.1 | 50.8 | 38.6-63.0 | — | — | — | — | — | — | |||
| No trisomy 12 | 45.1 | 55.6 | 46.3-64.8 | .6188 | — | — | — | — | — | — | — | — |
| Trisomy 12 | 40.3 | 51.7 | 44.9-58.6 | — | — | — | — | — | — | |||
| . | . | . | . | . | . | . | . | . | Internal bootstrapping validation . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Univariate analysis . | Multivariate analysis . | Bootstrap parameters (mean) . | |||||||||
| Characteristics . | 5-y PFS (%) . | Median PFS . | 95% CI . | P . | HR . | LCI . | UCI . | P . | HR . | LCI . | UCI . | Bootstrap selection (%) . |
| Age <65 y | 46.6 | 58.1 | 49.5-66.6 | .0617 | — | — | — | .2323 | — | — | — | 39.40 |
| Age ≥65 y | 42.9 | 46.5 | 36.0-56.9 | 1.23 | 0.87 | 1.75 | 1.24 | 0.87 | 1.78 | |||
| Binet A | 59.5 | 64.7 | 31.8-96.6 | .0848 | — | — | — | .1474 | — | — | — | 55.90 |
| Binet B+C | 43.5 | 54.3 | 48.3-60.3 | 1.57 | 0.85 | 2.91 | 1.72 | 0.88 | 3.4 | |||
| IGHV mutated | 58.6 | nr | na | .0005 | — | — | — | .0099 | — | — | — | 88.00 |
| IGHV unnmutated | 36.3 | 48.2 | 43.7-52.7 | 1.65 | 1.12 | 2.41 | 1.7 | 1.15 | 2.52 | |||
| No 11q deletion | 49.4 | 56.9 | 47.1-66.6 | .0106 | — | — | — | .0096 | — | — | — | 88.90 |
| 11q deletion | 18.4 | 43.5 | 32.2-54.7 | 1.67 | 1.13 | 2.46 | 1.67 | 1.16 | 2.56 | |||
| No 17p deletion | 48 | 58.9 | 49.3-68.4 | <.0001 | — | — | — | <.0001 | — | — | — | 100 |
| 17p deletion | 10.9 | 22.5 | 8.5-36.4 | 3.72 | 2.42 | 5.71 | 4.04 | 2.59 | 6.31 | |||
| Female | 50.1 | 66.2 | 50.5-82.0 | .324 | — | — | — | — | — | — | — | — |
| Male | 42.7 | 51.6 | 43.8-59.3 | — | — | — | — | — | — | |||
| No13q deletion | 45.4 | 55.6 | 48.3-62.8 | .9041 | — | — | — | — | — | — | — | — |
| 13q deletion | 41.1 | 50.8 | 38.6-63.0 | — | — | — | — | — | — | |||
| No trisomy 12 | 45.1 | 55.6 | 46.3-64.8 | .6188 | — | — | — | — | — | — | — | — |
| Trisomy 12 | 40.3 | 51.7 | 44.9-58.6 | — | — | — | — | — | — | |||
Shrinkage coefficient: 0.92.
Discrimination: bias-corrected c-index: 0.64; optimism: 0.02.
Calibration: bias-corrected calibration slope: 0.91; optimism: 0.09.
CI, confidence interval; LCI, lower confidence interval; n/a, not applicable; nr, not reached; UCI, upper confidence interval.