Stratified analysis of HLA-DRB1 and HLA-DQB1 matching on acute GVHD and survival
| HLA matching* . | N . | Acute GVHD (Grade III-IV)† . | Acute GVHD (Grade II-IV)† . | Mortality† . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | ||
| DRB1 match and DQB1 match | 5356 | 1.00 | 1.00 | 1.00 | ||||||
| DRB1 mismatch and DQB1 match | 325 | 0.98 | 0.74-1.28 | .866 | 1.19 | 1.00-1.42 | .046 | 1.04 | 0.88-1.22 | .662 |
| DRB1 match and DQB1 mismatch | 522 | 0.92 | 0.73-1.16 | .482 | 1.05 | 0.91-1.21 | .517 | 1.04 | 0.92-1.19 | .532 |
| DRB1 mismatch and DQB1 mismatch | 1695 | 1.32 | 1.16-1.50 | <.001 | 1.34 | 1.23-1.46 | <.001 | 1.17 | 1.08-1.27 | <.001 |
| HLA matching* . | N . | Acute GVHD (Grade III-IV)† . | Acute GVHD (Grade II-IV)† . | Mortality† . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | ||
| DRB1 match and DQB1 match | 5356 | 1.00 | 1.00 | 1.00 | ||||||
| DRB1 mismatch and DQB1 match | 325 | 0.98 | 0.74-1.28 | .866 | 1.19 | 1.00-1.42 | .046 | 1.04 | 0.88-1.22 | .662 |
| DRB1 match and DQB1 mismatch | 522 | 0.92 | 0.73-1.16 | .482 | 1.05 | 0.91-1.21 | .517 | 1.04 | 0.92-1.19 | .532 |
| DRB1 mismatch and DQB1 mismatch | 1695 | 1.32 | 1.16-1.50 | <.001 | 1.34 | 1.23-1.46 | <.001 | 1.17 | 1.08-1.27 | <.001 |
Multivariable competing risk regression analyses were conducted to evaluate the impact of acute GVHD and Cox proportional regression model for mortality. RR of the combination of HLA-DRB1 and/or -DQB1 mismatch was compared with HLA-DRB1 and -DQB1 match. Adjusted confounders were HLA-A, -B, -C, and -DPB1 locus matching and the clinical factors listed in Table 1.
GVH direction.
Survived 7 or more days.