Effect of HLA locus matching on leukemia relapse, engraftment, and mortality
| HLA . | Match or mismatch* . | Leukemia relapse† . | Engraftment‡ . | Mortality . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N . | RR . | 95% CI . | P . | N . | RR . | 95% CI . | P . | N . | RR . | 95% CI . | P . | ||
| A | Match | 4847 | 1.00 | .381 | 6898 | 1.00 | .035 | 7048 | 1.00 | <.001 | |||
| Mismatch | 606 | 0.92 | 0.76-1.11 | 851 | 0.93 | 0.87-0.99 | 850 | 1.29 | 1.17-1.42 | ||||
| B | Match | 5163 | 1.00 | .493 | 7320 | 1.00 | .146 | 7475 | 1.00 | <.001 | |||
| Mismatch | 290 | 0.91 | 0.69-1.20 | 429 | 0.93 | 0.84-1.03 | 423 | 1.27 | 1.11-1.45 | ||||
| C | Match | 3865 | 1.00 | <.001 | 5511 | 1.00 | .049 | 5565 | 1.00 | <.001 | |||
| Mismatch | 1588 | 0.70 | 0.61-0.80 | 2238 | 0.95 | 0.90-1.00 | 2333 | 1.21 | 1.13-1.30 | ||||
| DRB1 | Match | 4045 | 1.00 | .468 | 5763 | 1.00 | .212 | 5878 | 1.00 | .125 | |||
| Mismatch | 1408 | 0.93 | 0.76-1.14 | 1986 | 0.95 | 0.89-1.03 | 2020 | 1.09 | 0.98-1.21 | ||||
| DQB1 | Match | 3924 | 1.00 | .974 | 5583 | 1.00 | .014 | 5681 | 1.00 | .145 | |||
| Mismatch | 1529 | 1.00 | 0.83-1.22 | 2166 | 0.91 | 0.85-0.98 | 2217 | 1.08 | 0.97-1.19 | ||||
| DPB1 | Match | 1792 | 1.00 | <.001 | 2531 | 1.00 | .126 | 2604 | 1.00 | .349 | |||
| Mismatch | 3661 | 0.69 | 0.61-0.77 | 5218 | 0.97 | 0.92-1.01 | 5294 | 1.03 | 0.96-1.11 | ||||
| HLA . | Match or mismatch* . | Leukemia relapse† . | Engraftment‡ . | Mortality . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N . | RR . | 95% CI . | P . | N . | RR . | 95% CI . | P . | N . | RR . | 95% CI . | P . | ||
| A | Match | 4847 | 1.00 | .381 | 6898 | 1.00 | .035 | 7048 | 1.00 | <.001 | |||
| Mismatch | 606 | 0.92 | 0.76-1.11 | 851 | 0.93 | 0.87-0.99 | 850 | 1.29 | 1.17-1.42 | ||||
| B | Match | 5163 | 1.00 | .493 | 7320 | 1.00 | .146 | 7475 | 1.00 | <.001 | |||
| Mismatch | 290 | 0.91 | 0.69-1.20 | 429 | 0.93 | 0.84-1.03 | 423 | 1.27 | 1.11-1.45 | ||||
| C | Match | 3865 | 1.00 | <.001 | 5511 | 1.00 | .049 | 5565 | 1.00 | <.001 | |||
| Mismatch | 1588 | 0.70 | 0.61-0.80 | 2238 | 0.95 | 0.90-1.00 | 2333 | 1.21 | 1.13-1.30 | ||||
| DRB1 | Match | 4045 | 1.00 | .468 | 5763 | 1.00 | .212 | 5878 | 1.00 | .125 | |||
| Mismatch | 1408 | 0.93 | 0.76-1.14 | 1986 | 0.95 | 0.89-1.03 | 2020 | 1.09 | 0.98-1.21 | ||||
| DQB1 | Match | 3924 | 1.00 | .974 | 5583 | 1.00 | .014 | 5681 | 1.00 | .145 | |||
| Mismatch | 1529 | 1.00 | 0.83-1.22 | 2166 | 0.91 | 0.85-0.98 | 2217 | 1.08 | 0.97-1.19 | ||||
| DPB1 | Match | 1792 | 1.00 | <.001 | 2531 | 1.00 | .126 | 2604 | 1.00 | .349 | |||
| Mismatch | 3661 | 0.69 | 0.61-0.77 | 5218 | 0.97 | 0.92-1.01 | 5294 | 1.03 | 0.96-1.11 | ||||
Multivariable competing risk regression analyses were conducted to evaluate the impact of leukemia relapse and neutrophil engraftment, and a Cox proportional regression model was conducted for mortality. RR of respective HLA locus mismatches at the allele level was compared with HLA match adjusted with other HLA locus matching and the clinical factors listed in Table 1 for leukemia relapse and mortality. Transplanted cell number and ABO blood type matching were added for neutrophil engraftment.
GVH direction for leukemia relapse and mortality; HVG direction for engraftment.
At 5 years after transplantation.
Neutrophil recovery to successive >500 per microliter measurement at 3 time points in 100 days.