Effect of HLA locus matching on acute GVHD and chronic GVHD in a multivariable competing risk regression model
HLA . | Match or mismatch* . | N . | Acute GVHD (Grade III-IV)† . | Acute GVHD (Grade II-IV)† . | N . | Chronic GVHD‡ . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | ||||
A | Match | 7048 | 1.00 | .001 | 1.00 | .002 | 5892 | 1.00 | .328 | |||
Mismatch | 850 | 1.29 | 1.10-1.51 | 1.18 | 1.06-1.32 | 636 | 1.06 | 0.94-1.21 | ||||
B | Match | 7475 | 1.00 | .001 | 1.00 | .001 | 6217 | 1.00 | .235 | |||
Mismatch | 423 | 1.42 | 1.16-1.73 | 1.28 | 1.11-1.48 | 311 | 1.10 | 0.94-1.30 | ||||
C | Match | 5565 | 1.00 | <.001 | 1.00 | <.001 | 4716 | 1.00 | <.001 | |||
Mismatch | 2333 | 1.63 | 1.45-1.83 | 1.27 | 1.17-1.37 | 1812 | 1.24 | 1.13-1.35 | ||||
DRB1 | Match | 5878 | 1.00 | .022 | 1.00 | <.001 | 4936 | 1.00 | .262 | |||
Mismatch | 2020 | 1.21 | 1.03-1.43 | 1.24 | 1.11-1.39 | 1592 | 0.93 | 0.82-1.05 | ||||
DQB1 | Match | 5681 | 1.00 | .336 | 1.00 | .126 | 4758 | 1.00 | .018 | |||
Mismatch | 2217 | 1.08 | 0.92-1.27 | 1.09 | 0.98-1.22 | 1770 | 1.15 | 1.03-1.30 | ||||
DPB1 | Match | 2604 | 1.00 | .001 | 1.00 | <.001 | 2223 | 1.00 | .367 | |||
Mismatch | 5294 | 1.23 | 1.09-1.38 | 1.36 | 1.26-1.47 | 4305 | 1.04 | 0.96-1.12 |
HLA . | Match or mismatch* . | N . | Acute GVHD (Grade III-IV)† . | Acute GVHD (Grade II-IV)† . | N . | Chronic GVHD‡ . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | ||||
A | Match | 7048 | 1.00 | .001 | 1.00 | .002 | 5892 | 1.00 | .328 | |||
Mismatch | 850 | 1.29 | 1.10-1.51 | 1.18 | 1.06-1.32 | 636 | 1.06 | 0.94-1.21 | ||||
B | Match | 7475 | 1.00 | .001 | 1.00 | .001 | 6217 | 1.00 | .235 | |||
Mismatch | 423 | 1.42 | 1.16-1.73 | 1.28 | 1.11-1.48 | 311 | 1.10 | 0.94-1.30 | ||||
C | Match | 5565 | 1.00 | <.001 | 1.00 | <.001 | 4716 | 1.00 | <.001 | |||
Mismatch | 2333 | 1.63 | 1.45-1.83 | 1.27 | 1.17-1.37 | 1812 | 1.24 | 1.13-1.35 | ||||
DRB1 | Match | 5878 | 1.00 | .022 | 1.00 | <.001 | 4936 | 1.00 | .262 | |||
Mismatch | 2020 | 1.21 | 1.03-1.43 | 1.24 | 1.11-1.39 | 1592 | 0.93 | 0.82-1.05 | ||||
DQB1 | Match | 5681 | 1.00 | .336 | 1.00 | .126 | 4758 | 1.00 | .018 | |||
Mismatch | 2217 | 1.08 | 0.92-1.27 | 1.09 | 0.98-1.22 | 1770 | 1.15 | 1.03-1.30 | ||||
DPB1 | Match | 2604 | 1.00 | .001 | 1.00 | <.001 | 2223 | 1.00 | .367 | |||
Mismatch | 5294 | 1.23 | 1.09-1.38 | 1.36 | 1.26-1.47 | 4305 | 1.04 | 0.96-1.12 |