Univariate and multiple linear regression for associations with hepcidin overall and in moderate and severe groups
| Variable . | Overall group . | Moderate phenotype . | Severe phenotype . | |||
|---|---|---|---|---|---|---|
| β Coefficient* . | P . | β Coefficient . | P . | β Coefficient . | P . | |
| Univariate linear regression | ||||||
| Age | −0.05 | .683 | 0.05 | .744 | −0.24 | .217 |
| Sex | 0.06 | .623 | −0.05 | .775 | 0.19 | .331 |
| Lifetime transfusions | −0.16 | .183 | −0.30 | .061 | −0.04 | .855 |
| Splenectomy† | −0.48 | <.001‡ | −0.53 | <.001‡ | −0.42 | .025‡ |
| Severity¶ | 0.04 | .744 | — | — | — | — |
| Interaction between splenectomy and severity | 0.00 | .988 | — | — | ||
| Erythropoiesis | ||||||
| Hemoglobin | 0.13 | .308 | −0.06 | .738 | 0.44 | .037‡ |
| Erythropoietin§ | −0.08 | .516 | 0.17 | .297 | −0.39 | .062 |
| sTfR§ | −0.36 | .003‡ | −0.22 | .165 | −0.52 | .006‡ |
| GDF-15§ | −0.23 | .057 | −0.03 | .853 | −0.49 | .008‡ |
| Iron indices | ||||||
| Ferritin§ | 0.00 | .993 | −0.33 | .043‡ | 0.31 | .114 |
| Liver iron loading§ | 0.11 | .381 | −0.04 | .824 | 0.26 | .184 |
| Transferrin saturation | −0.19 | .131 | −0.27 | .098 | −0.12 | .565 |
| NTBI | −0.42 | <.001‡ | −0.46 | .003‡ | −0.45 | .018‡ |
| Labile plasma iron | −0.26 | .034‡ | −0.33 | .043‡ | −0.16 | .412 |
| ALT§ | 0.05 | .687 | −0.18 | .279 | 0.23 | .244 |
| CRP§ | −0.13 | .297 | −0.20 | .231 | −0.08 | .707 |
| Multiple linear regression | ||||||
| sTfR | −0.34‖ | .001 | — | −0.45** | .010 | |
| Splenectomy | −0.47‖ | <.001 | −0.53 | <.001 | −0.36** | .037 |
| Variable . | Overall group . | Moderate phenotype . | Severe phenotype . | |||
|---|---|---|---|---|---|---|
| β Coefficient* . | P . | β Coefficient . | P . | β Coefficient . | P . | |
| Univariate linear regression | ||||||
| Age | −0.05 | .683 | 0.05 | .744 | −0.24 | .217 |
| Sex | 0.06 | .623 | −0.05 | .775 | 0.19 | .331 |
| Lifetime transfusions | −0.16 | .183 | −0.30 | .061 | −0.04 | .855 |
| Splenectomy† | −0.48 | <.001‡ | −0.53 | <.001‡ | −0.42 | .025‡ |
| Severity¶ | 0.04 | .744 | — | — | — | — |
| Interaction between splenectomy and severity | 0.00 | .988 | — | — | ||
| Erythropoiesis | ||||||
| Hemoglobin | 0.13 | .308 | −0.06 | .738 | 0.44 | .037‡ |
| Erythropoietin§ | −0.08 | .516 | 0.17 | .297 | −0.39 | .062 |
| sTfR§ | −0.36 | .003‡ | −0.22 | .165 | −0.52 | .006‡ |
| GDF-15§ | −0.23 | .057 | −0.03 | .853 | −0.49 | .008‡ |
| Iron indices | ||||||
| Ferritin§ | 0.00 | .993 | −0.33 | .043‡ | 0.31 | .114 |
| Liver iron loading§ | 0.11 | .381 | −0.04 | .824 | 0.26 | .184 |
| Transferrin saturation | −0.19 | .131 | −0.27 | .098 | −0.12 | .565 |
| NTBI | −0.42 | <.001‡ | −0.46 | .003‡ | −0.45 | .018‡ |
| Labile plasma iron | −0.26 | .034‡ | −0.33 | .043‡ | −0.16 | .412 |
| ALT§ | 0.05 | .687 | −0.18 | .279 | 0.23 | .244 |
| CRP§ | −0.13 | .297 | −0.20 | .231 | −0.08 | .707 |
| Multiple linear regression | ||||||
| sTfR | −0.34‖ | .001 | — | −0.45** | .010 | |
| Splenectomy | −0.47‖ | <.001 | −0.53 | <.001 | −0.36** | .037 |
β coefficient was performed on variables standardized to have a variance of 1, enabling comparison of coefficients between variables.
Splenectomy status coded as: splenectomized = 1, non-splenectomized = 0.
Significant association (P < 0.05).
Severity coded as Severe = 1, Moderate = 0.
Log-transformed.
R2 = 0.35.
R2 = 0.39.