Factors which retained a significant effect on overall survival on multivariate analysis within the hyperdiploid population
| Factor . | HR . | 95% CI . | P . |
|---|---|---|---|
| ISS (I vs II/III) | 1.67 | 1.15-2.43 | .007 |
| Pathway (intensive vs nonintensive) | 2.04 | 1.56-2.66 | <.001 |
| Chemotherapy (thalidomide based vs traditional) | 1.48 | 1.14-1.93 | .004 |
| Adverse cytogenetics (any of adverse IGH, del17p, or +1q present vs absent) | 1.78 | 1.36-2.33 | <.001 |
| Factor . | HR . | 95% CI . | P . |
|---|---|---|---|
| ISS (I vs II/III) | 1.67 | 1.15-2.43 | .007 |
| Pathway (intensive vs nonintensive) | 2.04 | 1.56-2.66 | <.001 |
| Chemotherapy (thalidomide based vs traditional) | 1.48 | 1.14-1.93 | .004 |
| Adverse cytogenetics (any of adverse IGH, del17p, or +1q present vs absent) | 1.78 | 1.36-2.33 | <.001 |
A backward fitted Cox regression analysis was performed and included all variables found to have a significant impact on OS in univariate analysis. A total of 137 of 499 patients were excluded, as there were incomplete ISS data.
HR, hazard ratio.