Yield of human platelets per megakaryocyte infused into NSG mice with or without liposomal clodronate treatment
| Clodronate liposomes . | Per AMC-derived cell . | Per FLC-derived cell . | Per iPSC-derived cell . |
|---|---|---|---|
| No treatment | 32 ± 4 (N = 8) | 15 ± 3 (N = 6) | 3 ± 1 (N = 6) |
| Treated | 54 ± 6 (N = 7) | Not done | 15 ± 3 (N = 13) |
| Clodronate liposomes . | Per AMC-derived cell . | Per FLC-derived cell . | Per iPSC-derived cell . |
|---|---|---|---|
| No treatment | 32 ± 4 (N = 8) | 15 ± 3 (N = 6) | 3 ± 1 (N = 6) |
| Treated | 54 ± 6 (N = 7) | Not done | 15 ± 3 (N = 13) |
The number of released platelets per total cells infused determined by assuming that a 20-g mouse has a blood volume of 2 mL and that every nucleated cell infused releases platelets. Based on peak percent of platelets that are infused. Mean ± SEM is shown with the number (N) of separate experiments, each done in duplicate, in parentheses.