Gene-based test meta-analysis results for hemostatic factors fibrinogen, FVII, FVIII, and vWF
| Factor and gene . | Ancestry . | No. of participants included in analysis . | P . | |
|---|---|---|---|---|
| SKAT5 . | T5 . | |||
| Fibrinogen | ||||
| FGB | ALL | 76 316 | 1.25E-45 | 5.59E-32 |
| EUR | 65 733 | 2.03E-44 | 1.16E-36 | |
| AFR | 8 388 | 4.50E-01 | 5.60E-01 | |
| ASI | 764 | 3.00E-01 | 2.98E-01 | |
| HIS | 1 431 | 9.37E-01 | 9.39E-01 | |
| FGG | ALL | 76 316 | 6.90E-99 | 7.25E-31 |
| EUR | 65 733 | 2.49E-111 | 1.35E-61 | |
| AFR | 8 388 | 2.82E-09 | 3.18E-04 | |
| ASI | 764 | NA | NA | |
| HIS | 1 431 | 5.65E-01 | 8.18E-01 | |
| FVII | ||||
| F7 | ALL | 25 372 | 6.24E-35 | 2.36E-37 |
| EUR | 20 401 | 6.71E-05 | 8.21E-07 | |
| AFR | 4 971 | 1.83E-35 | 3.03E-32 | |
| FVIII | ||||
| ABO | ALL | 28 291 | 5.10E-18 | 5.71E-30 |
| EUR | 20 030 | 1.90E-13 | 1.61E-17 | |
| AFR | 6 079 | 1.91E-03 | 3.44E-04 | |
| ASI | 764 | 8.37E-01 | 9.56E-01 | |
| HIS | 1 418 | 3.48E-01 | 2.89E-02 | |
| VWF | ALL | 28 291 | 5.21E-21 | 1.61E-06 |
| EUR | 20 030 | 2.20E-07 | 1.47E-04 | |
| AFR | 6 079 | 8.13E-03 | 4.09E-01 | |
| ASI | 764 | 1.41E-01 | 8.01E-01 | |
| HIS | 1 418 | 2.27E-01 | 4.07E-01 | |
| STAB2 | ALL | 28 291 | 3.49E-07 | 2.56E-03 |
| EUR | 20 030 | 6.49E-07 | 5.83E-03 | |
| AFR | 6 079 | 1.44E-01 | 8.23E-02 | |
| ASI | 764 | 1.78E-01 | 9.55E-02 | |
| HIS | 1 418 | 9.13E-01 | 3.09E-01 | |
| vWF | ||||
| ABO | ALL | 23 272 | 4.07E-19 | 3.69E-29 |
| EUR | 18 236 | 2.84E-13 | 4.17E-18 | |
| AFR | 5 036 | 2.89E-03 | 3.01E-04 | |
| STAB2 | ALL | 23 272 | 2.99E-07 | 8.07E-03 |
| EUR | 18 236 | 1.53E-06 | 1.66E-01 | |
| AFR | 5 036 | 7.24E-04 | 6.46E-02 | |
| Factor and gene . | Ancestry . | No. of participants included in analysis . | P . | |
|---|---|---|---|---|
| SKAT5 . | T5 . | |||
| Fibrinogen | ||||
| FGB | ALL | 76 316 | 1.25E-45 | 5.59E-32 |
| EUR | 65 733 | 2.03E-44 | 1.16E-36 | |
| AFR | 8 388 | 4.50E-01 | 5.60E-01 | |
| ASI | 764 | 3.00E-01 | 2.98E-01 | |
| HIS | 1 431 | 9.37E-01 | 9.39E-01 | |
| FGG | ALL | 76 316 | 6.90E-99 | 7.25E-31 |
| EUR | 65 733 | 2.49E-111 | 1.35E-61 | |
| AFR | 8 388 | 2.82E-09 | 3.18E-04 | |
| ASI | 764 | NA | NA | |
| HIS | 1 431 | 5.65E-01 | 8.18E-01 | |
| FVII | ||||
| F7 | ALL | 25 372 | 6.24E-35 | 2.36E-37 |
| EUR | 20 401 | 6.71E-05 | 8.21E-07 | |
| AFR | 4 971 | 1.83E-35 | 3.03E-32 | |
| FVIII | ||||
| ABO | ALL | 28 291 | 5.10E-18 | 5.71E-30 |
| EUR | 20 030 | 1.90E-13 | 1.61E-17 | |
| AFR | 6 079 | 1.91E-03 | 3.44E-04 | |
| ASI | 764 | 8.37E-01 | 9.56E-01 | |
| HIS | 1 418 | 3.48E-01 | 2.89E-02 | |
| VWF | ALL | 28 291 | 5.21E-21 | 1.61E-06 |
| EUR | 20 030 | 2.20E-07 | 1.47E-04 | |
| AFR | 6 079 | 8.13E-03 | 4.09E-01 | |
| ASI | 764 | 1.41E-01 | 8.01E-01 | |
| HIS | 1 418 | 2.27E-01 | 4.07E-01 | |
| STAB2 | ALL | 28 291 | 3.49E-07 | 2.56E-03 |
| EUR | 20 030 | 6.49E-07 | 5.83E-03 | |
| AFR | 6 079 | 1.44E-01 | 8.23E-02 | |
| ASI | 764 | 1.78E-01 | 9.55E-02 | |
| HIS | 1 418 | 9.13E-01 | 3.09E-01 | |
| vWF | ||||
| ABO | ALL | 23 272 | 4.07E-19 | 3.69E-29 |
| EUR | 18 236 | 2.84E-13 | 4.17E-18 | |
| AFR | 5 036 | 2.89E-03 | 3.01E-04 | |
| STAB2 | ALL | 23 272 | 2.99E-07 | 8.07E-03 |
| EUR | 18 236 | 1.53E-06 | 1.66E-01 | |
| AFR | 5 036 | 7.24E-04 | 6.46E-02 | |
Genes that achieved genome-wide significance (P < 1.85E-06) are shown in bold.