Global treatment-related toxicity rates
| . | Nonhematologic . | Hematologic and nonhematologic . | ||||
|---|---|---|---|---|---|---|
| Worst grade by patient . | No. of patients . | Grade 3-5 . | Rate . | No. of patients . | Grade 4-5 . | Rate . |
| Overall | ||||||
| MPT-T | 148 | 88 | 59.5% | 148 | 61 | 41.2% |
| mPR-R | 150 | 60 | 40.0% | 150 | 49 | 32.7% |
| Difference | — | — | 19.5% | — | — | 8.5% |
| P value | — | — | .001 | — | — | .150 |
| During induction | ||||||
| MPT | 148 | 75 | 50.7% | 148 | 54 | 36.5% |
| mPR-R | 150 | 54 | 36.0% | 150 | 45 | 30.0% |
| Difference | — | — | 14.7% | — | — | 6.5% |
| P value | — | — | .014 | — | — | .269 |
| During maintenance | ||||||
| MPT-T | 70 | 19 | 27.1% | 70 | 6 | 8.6% |
| mPR-R | 69 | 11 | 15.9% | 69 | 6 | 8.7% |
| Difference | — | — | 11.2% | — | — | −0.1% |
| P value | — | — | .149 | — | — | 1.000 |
| Age ≥75 y | ||||||
| MPT-T | 89 | 51 | 57.3% | 89 | 39 | 43.8% |
| mPR-R | 88 | 37 | 42.0% | 88 | 31 | 35.2% |
| Difference | — | — | 15.3% | — | — | 8.6% |
| P value | — | — | .051 | — | — | .283 |
| Age <75 y | ||||||
| MPT-T | 59 | 37 | 62.7% | 59 | 22 | 37.3% |
| mPR-R | 62 | 23 | 37.1% | 62 | 18 | 29.0% |
| Total | 121 | 60 | 49.6% | 121 | 40 | 33.1% |
| Difference | — | — | 25.6% | — | — | 0.4% |
| P value | — | — | .006 | — | — | .440 |
| . | Nonhematologic . | Hematologic and nonhematologic . | ||||
|---|---|---|---|---|---|---|
| Worst grade by patient . | No. of patients . | Grade 3-5 . | Rate . | No. of patients . | Grade 4-5 . | Rate . |
| Overall | ||||||
| MPT-T | 148 | 88 | 59.5% | 148 | 61 | 41.2% |
| mPR-R | 150 | 60 | 40.0% | 150 | 49 | 32.7% |
| Difference | — | — | 19.5% | — | — | 8.5% |
| P value | — | — | .001 | — | — | .150 |
| During induction | ||||||
| MPT | 148 | 75 | 50.7% | 148 | 54 | 36.5% |
| mPR-R | 150 | 54 | 36.0% | 150 | 45 | 30.0% |
| Difference | — | — | 14.7% | — | — | 6.5% |
| P value | — | — | .014 | — | — | .269 |
| During maintenance | ||||||
| MPT-T | 70 | 19 | 27.1% | 70 | 6 | 8.6% |
| mPR-R | 69 | 11 | 15.9% | 69 | 6 | 8.7% |
| Difference | — | — | 11.2% | — | — | −0.1% |
| P value | — | — | .149 | — | — | 1.000 |
| Age ≥75 y | ||||||
| MPT-T | 89 | 51 | 57.3% | 89 | 39 | 43.8% |
| mPR-R | 88 | 37 | 42.0% | 88 | 31 | 35.2% |
| Difference | — | — | 15.3% | — | — | 8.6% |
| P value | — | — | .051 | — | — | .283 |
| Age <75 y | ||||||
| MPT-T | 59 | 37 | 62.7% | 59 | 22 | 37.3% |
| mPR-R | 62 | 23 | 37.1% | 62 | 18 | 29.0% |
| Total | 121 | 60 | 49.6% | 121 | 40 | 33.1% |
| Difference | — | — | 25.6% | — | — | 0.4% |
| P value | — | — | .006 | — | — | .440 |