Baseline characteristics of the unmatched and matched cohorts
| . | Unmatched cohort . | Matched cohort . | ||||
|---|---|---|---|---|---|---|
| . | Argatroban/danaparoid (n = 106) . | Fondaparinux (n = 133) . | P* . | Argatroban/danaparoid (n = 60) . | Fondaparinux (n = 133) . | P* . |
| Age, years, median (IQR) | 68 (58-77) | 68 (61-78) | .511 | 67 (58-77) | 68 (61-78) | .537 |
| Male gender, N (%) | 50 (47.2) | 64 (48.1) | .884 | 30 (29.1) | 64 (48.1) | .809 |
| Length of hospital stay, days (mean [SD]) | 42.6 (33.1) | 39.1 (43.7) | .489 | 42.6 (35.9) | 39.1 (43.7) | .585 |
| Creatinine, mmol/L (median [IQR]) | 152 (81-250) | 90 (62-125) | <.001 | 96 (59-166) | 90 (62-125) | .238 |
| Duration of alternative anticoagulation, days (median [IQR]) | 4 (2-10) | 4 (2-10) | .637 | 4 (2-7) | 4 (2-10) | .326 |
| Indication for anticoagulation, N (%) | ||||||
| Venous thromboembolism | 24 (22.6) | 40 (30.1) | .197 | 17 (28.3) | 40 (30.1) | .806 |
| Arterial thrombosis | 7 (6.6) | 10 (7.5) | .785 | 4 (6.7) | 10 (7.5) | 1.0 |
| Prosthetic mechanical heart valve | 8 (7.5) | 7 (5.3) | .470 | 4 (6.7) | 7 (5.3) | .741 |
| Charlson comorbidity index, median (IQR) | 2 (1-3) | 1 (0−2) | .030 | 1 (0-2) | 1 (0-2) | .945 |
| 4T score, median (IQR) | 4 (3-6) | 5 (3-6) | .707 | 4 (3-6) | 5 (3-6) | .439 |
| 4T score category, N (%) | .018 | .008 | ||||
| Low probability (0-3) | 39 (36.8) | 38 (28.6) | — | 25 (41.7) | 38 (28.6) | — |
| Intermediate probability (4-5) | 29 (27.4) | 60 (45.1) | — | 13 (21.7) | 60 (45.1) | — |
| High probability (6-8) | 38 (35.8) | 35 (26.3) | — | 22 (36.7) | 35 (26.3) | — |
| HIT-ELISA test result, N (%) | .813 | .199 | ||||
| Negative | 57 (53.8) | 69 (51.9) | — | 39 (65.0) | 69 (51.9) | — |
| Equivocal | 13 (12.3) | 14 (10.5) | — | 6 (10.0) | 14 (10.5) | — |
| Positive | 36 (34.0) | 50 (37.6) | — | 15 (25.0) | 50 (37.6) | — |
| HIT diagnosis during admission, N (%) | 38 (35.8) | 44 (33.1) | .654 | 20 (33.3) | 44 (33.1) | .973 |
| . | Unmatched cohort . | Matched cohort . | ||||
|---|---|---|---|---|---|---|
| . | Argatroban/danaparoid (n = 106) . | Fondaparinux (n = 133) . | P* . | Argatroban/danaparoid (n = 60) . | Fondaparinux (n = 133) . | P* . |
| Age, years, median (IQR) | 68 (58-77) | 68 (61-78) | .511 | 67 (58-77) | 68 (61-78) | .537 |
| Male gender, N (%) | 50 (47.2) | 64 (48.1) | .884 | 30 (29.1) | 64 (48.1) | .809 |
| Length of hospital stay, days (mean [SD]) | 42.6 (33.1) | 39.1 (43.7) | .489 | 42.6 (35.9) | 39.1 (43.7) | .585 |
| Creatinine, mmol/L (median [IQR]) | 152 (81-250) | 90 (62-125) | <.001 | 96 (59-166) | 90 (62-125) | .238 |
| Duration of alternative anticoagulation, days (median [IQR]) | 4 (2-10) | 4 (2-10) | .637 | 4 (2-7) | 4 (2-10) | .326 |
| Indication for anticoagulation, N (%) | ||||||
| Venous thromboembolism | 24 (22.6) | 40 (30.1) | .197 | 17 (28.3) | 40 (30.1) | .806 |
| Arterial thrombosis | 7 (6.6) | 10 (7.5) | .785 | 4 (6.7) | 10 (7.5) | 1.0 |
| Prosthetic mechanical heart valve | 8 (7.5) | 7 (5.3) | .470 | 4 (6.7) | 7 (5.3) | .741 |
| Charlson comorbidity index, median (IQR) | 2 (1-3) | 1 (0−2) | .030 | 1 (0-2) | 1 (0-2) | .945 |
| 4T score, median (IQR) | 4 (3-6) | 5 (3-6) | .707 | 4 (3-6) | 5 (3-6) | .439 |
| 4T score category, N (%) | .018 | .008 | ||||
| Low probability (0-3) | 39 (36.8) | 38 (28.6) | — | 25 (41.7) | 38 (28.6) | — |
| Intermediate probability (4-5) | 29 (27.4) | 60 (45.1) | — | 13 (21.7) | 60 (45.1) | — |
| High probability (6-8) | 38 (35.8) | 35 (26.3) | — | 22 (36.7) | 35 (26.3) | — |
| HIT-ELISA test result, N (%) | .813 | .199 | ||||
| Negative | 57 (53.8) | 69 (51.9) | — | 39 (65.0) | 69 (51.9) | — |
| Equivocal | 13 (12.3) | 14 (10.5) | — | 6 (10.0) | 14 (10.5) | — |
| Positive | 36 (34.0) | 50 (37.6) | — | 15 (25.0) | 50 (37.6) | — |
| HIT diagnosis during admission, N (%) | 38 (35.8) | 44 (33.1) | .654 | 20 (33.3) | 44 (33.1) | .973 |
ELISA, enzyme-linked immunosorbent assay; HIT, heparin-induced thrombocytopenia; IQR, interquartile range; SD, standard deviation.
χ2 or Fisher’s exact test for categorical variables, Mann Whitney U, or Student t test for continuous variables.