Expression of major surface GPs on Dnm2-null platelets
| Platelet GP . | Dnm2fl/fl . | Dnm2fl/flPf4-Cre . | P . |
|---|---|---|---|
| GPIbα (CD42b) | 149 ± 13 | 153 ± 10 | NS |
| GPIbβ (CD42c) | 462 ± 16 | 591 ± 34 | .0094 |
| GPIX (CD42a) | 101 ± 19 | 177 ± 21 | .0262 |
| GPV (CD42d) | 85 ± 1 | 79 ± 3 | NS |
| GPIIIa (CD61, integrin β3) | 142 ± 7 | 289 ± 6 | <.0001 |
| GPVI | 34 ± 2 | 21 ± 1 | .0014 |
| Platelet GP . | Dnm2fl/fl . | Dnm2fl/flPf4-Cre . | P . |
|---|---|---|---|
| GPIbα (CD42b) | 149 ± 13 | 153 ± 10 | NS |
| GPIbβ (CD42c) | 462 ± 16 | 591 ± 34 | .0094 |
| GPIX (CD42a) | 101 ± 19 | 177 ± 21 | .0262 |
| GPV (CD42d) | 85 ± 1 | 79 ± 3 | NS |
| GPIIIa (CD61, integrin β3) | 142 ± 7 | 289 ± 6 | <.0001 |
| GPVI | 34 ± 2 | 21 ± 1 | .0014 |
Platelets from control Dnm2fl/fl and Dnm2fl/flPf4-Cre mice were incubated with fluorescently labeled antibodies directed against the indicated platelet GPs. Data are expressed as mean fluorescence intensity and represent mean ± SEM (n = 5 in each group).
NS, not significant.