Risk factors for mortality from all causes or respiratory failure by day 100 after diagnosis of IPS, N = 69
| . | Univariable analysis . | Multivariable analysis . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Overall mortality | ||||||
| Donor type | ||||||
| Matched related | 1.00 | 1.00 | ||||
| Mismatched related/unrelated | 0.48 | 0.28-0.84 | .01 | 0.54 | 0.30-0.95 | .03 |
| Bacteremia/candidemia | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 2.59 | 0.92-7.31 | .07 | 3.09 | 1.06-9.04 | .04 |
| Steroid dose before diagnosis | ||||||
| No | 1.00 | 1.00 | ||||
| ≤1 mg/kg | 2.25 | 1.09-4.65 | .03 | 1.75 | 0.99-3.10 | .05 |
| >1 mg/kg | 2.13 | 1.15-3.95 | .02 | |||
| Steroid dose after diagnosis* | ||||||
| ≤2 mg/kg | 1.00 | 1.00 | ||||
| >2 mg/kg | 2.86 | 1.07-7.63 | .04 | 3.56 | 1.18-10.77 | .02 |
| DAH | ||||||
| No | 1.00 | |||||
| Yes | 1.73 | 0.98-3.06 | .06 | |||
| Detected pathogen | ||||||
| None | 1.00 | 1.00 | ||||
| Established | 1.80 | 0.94-3.43 | .08 | 1.88 | 1.06-3.34 | .03 |
| Uncertain | 1.78 | 0.92-3.47 | .09 | |||
| Viral load† | ||||||
| Low | 1.00 | |||||
| High | 0.71 | 0.32-1.55 | .38 | |||
| Mortality from respiratory failure | ||||||
| Donor type | ||||||
| Matched related | 1.00 | 1.00 | ||||
| Mismatched related/unrelated | 0.48 | 0.26-0.91 | .02 | 0.54 | 0.29-1.04 | .06 |
| Bacteremia/candidemia | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 3.11 | 1.09-8.88 | .03 | 3.76 | 1.25-11.37 | .02 |
| Steroid dose before diagnosis | ||||||
| No | 1.00 | 1.00 | ||||
| ≤1 mg/kg | 2.99 | 1.33-6.71 | .008 | 2.20 | 1.12-4.29 | .02 |
| >1 mg/kg | 2.84 | 1.40-5.77 | .004 | |||
| Steroid dose after diagnosis* | ||||||
| ≤2 mg/kg | 1.00 | 1.00 | ||||
| >2 mg/kg | 4.49 | 1.29-15.63 | .02 | 6.83 | 1.50-31.04 | .01 |
| DAH | ||||||
| No | 1.00 | |||||
| Yes | 2.59 | 1.39-4.83 | .003 | |||
| Detected pathogen | ||||||
| None | 1.00 | 1.00 | ||||
| Established | 2.09 | 0.99-4.43 | .05 | 2.28 | 1.15-4.52 | .02 |
| Uncertain | 2.24 | 1.05-4.79 | .04 | |||
| Viral load† | ||||||
| Low | 1.00 | |||||
| High | 0.50 | 0.20-1.26 | .14 | |||
| . | Univariable analysis . | Multivariable analysis . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Overall mortality | ||||||
| Donor type | ||||||
| Matched related | 1.00 | 1.00 | ||||
| Mismatched related/unrelated | 0.48 | 0.28-0.84 | .01 | 0.54 | 0.30-0.95 | .03 |
| Bacteremia/candidemia | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 2.59 | 0.92-7.31 | .07 | 3.09 | 1.06-9.04 | .04 |
| Steroid dose before diagnosis | ||||||
| No | 1.00 | 1.00 | ||||
| ≤1 mg/kg | 2.25 | 1.09-4.65 | .03 | 1.75 | 0.99-3.10 | .05 |
| >1 mg/kg | 2.13 | 1.15-3.95 | .02 | |||
| Steroid dose after diagnosis* | ||||||
| ≤2 mg/kg | 1.00 | 1.00 | ||||
| >2 mg/kg | 2.86 | 1.07-7.63 | .04 | 3.56 | 1.18-10.77 | .02 |
| DAH | ||||||
| No | 1.00 | |||||
| Yes | 1.73 | 0.98-3.06 | .06 | |||
| Detected pathogen | ||||||
| None | 1.00 | 1.00 | ||||
| Established | 1.80 | 0.94-3.43 | .08 | 1.88 | 1.06-3.34 | .03 |
| Uncertain | 1.78 | 0.92-3.47 | .09 | |||
| Viral load† | ||||||
| Low | 1.00 | |||||
| High | 0.71 | 0.32-1.55 | .38 | |||
| Mortality from respiratory failure | ||||||
| Donor type | ||||||
| Matched related | 1.00 | 1.00 | ||||
| Mismatched related/unrelated | 0.48 | 0.26-0.91 | .02 | 0.54 | 0.29-1.04 | .06 |
| Bacteremia/candidemia | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 3.11 | 1.09-8.88 | .03 | 3.76 | 1.25-11.37 | .02 |
| Steroid dose before diagnosis | ||||||
| No | 1.00 | 1.00 | ||||
| ≤1 mg/kg | 2.99 | 1.33-6.71 | .008 | 2.20 | 1.12-4.29 | .02 |
| >1 mg/kg | 2.84 | 1.40-5.77 | .004 | |||
| Steroid dose after diagnosis* | ||||||
| ≤2 mg/kg | 1.00 | 1.00 | ||||
| >2 mg/kg | 4.49 | 1.29-15.63 | .02 | 6.83 | 1.50-31.04 | .01 |
| DAH | ||||||
| No | 1.00 | |||||
| Yes | 2.59 | 1.39-4.83 | .003 | |||
| Detected pathogen | ||||||
| None | 1.00 | 1.00 | ||||
| Established | 2.09 | 0.99-4.43 | .05 | 2.28 | 1.15-4.52 | .02 |
| Uncertain | 2.24 | 1.05-4.79 | .04 | |||
| Viral load† | ||||||
| Low | 1.00 | |||||
| High | 0.50 | 0.20-1.26 | .14 | |||
All variables in Table 1 were used for the univariable analysis. Only variables with P < .1 are shown in this table. Viral load was shown regardless of P values.
HR, hazard ratio.
Peak steroid doses after diagnosis and the peak date were recorded from within 2 weeks after diagnosis.38 These variables are analyzed as time dependent.
This analysis was performed only among 38 patients with viral pathogens.