Meta-regression by disease genotype, country gross national income, and quality of study reporting
| . | Odds ratios . | P value (χ2) . | P value (LR test*) . | ||
|---|---|---|---|---|---|
| HbSS . | HbSC . | Nonspecified SCD . | |||
| Disease genotype | |||||
| Maternal mortality | No deaths | ||||
| Preeclampsia | 2.7 (1.8-3.9) | 1.9 (1.1-3.2) | 2.6 (2.4-2.8) | .43* | |
| Stillbirth | 4.0 (2.8-5.6) | 1.9 (1.04-3.4) | 3.7 (2.8-4.9) | .04* | |
| Preterm delivery | 2.2 (1.8-2.7) | 1.2 (0.8-1.6) | 1.6 (1.4-1.7) | .0007* | |
| Small for gestational age infants | 4.0 (3.1-5.2) | 1.6 (0.79-3.1) | 1.5 (1.2-1.8) | <.001 | |
| Country gross national income | GNI ≥ $30 000 | ||||
| Maternal mortality | 0.15 (0.02-0.86) | <.001 | |||
| Preeclampsia | 0.59 (0.24-1.42) | .24 | |||
| Stillbirth | 0.28 (0.14-0.55) | <.001 | |||
| Preterm delivery | 0.78 (0.40-1.51) | .46 | |||
| Small for gestational age infants | 0.89 (0.42-1.92) | .77 | |||
| Quality of study reporting | High quality | Low quality | |||
| Maternal mortality | 23.2 (13.5-40.1) | 11.2 (8.2-15.4) | <.001 | ||
| Preeclampsia | 3.1 (2.8-3.4) | 2.0 (1.7-2.2) | <.001 | ||
| Stillbirth | 6.5 (3.7-11.6) | 3.2 (2.6-4.1) | .03 | ||
| Preterm delivery | 2.7 (2.1-3.4) | 1.5 (1.4-1.6) | <.001 | ||
| Small for gestational age infants | 3.9 (3.0-5.0) | 1.5 (1.2-1.8) | <.001 | ||
| . | Odds ratios . | P value (χ2) . | P value (LR test*) . | ||
|---|---|---|---|---|---|
| HbSS . | HbSC . | Nonspecified SCD . | |||
| Disease genotype | |||||
| Maternal mortality | No deaths | ||||
| Preeclampsia | 2.7 (1.8-3.9) | 1.9 (1.1-3.2) | 2.6 (2.4-2.8) | .43* | |
| Stillbirth | 4.0 (2.8-5.6) | 1.9 (1.04-3.4) | 3.7 (2.8-4.9) | .04* | |
| Preterm delivery | 2.2 (1.8-2.7) | 1.2 (0.8-1.6) | 1.6 (1.4-1.7) | .0007* | |
| Small for gestational age infants | 4.0 (3.1-5.2) | 1.6 (0.79-3.1) | 1.5 (1.2-1.8) | <.001 | |
| Country gross national income | GNI ≥ $30 000 | ||||
| Maternal mortality | 0.15 (0.02-0.86) | <.001 | |||
| Preeclampsia | 0.59 (0.24-1.42) | .24 | |||
| Stillbirth | 0.28 (0.14-0.55) | <.001 | |||
| Preterm delivery | 0.78 (0.40-1.51) | .46 | |||
| Small for gestational age infants | 0.89 (0.42-1.92) | .77 | |||
| Quality of study reporting | High quality | Low quality | |||
| Maternal mortality | 23.2 (13.5-40.1) | 11.2 (8.2-15.4) | <.001 | ||
| Preeclampsia | 3.1 (2.8-3.4) | 2.0 (1.7-2.2) | <.001 | ||
| Stillbirth | 6.5 (3.7-11.6) | 3.2 (2.6-4.1) | .03 | ||
| Preterm delivery | 2.7 (2.1-3.4) | 1.5 (1.4-1.6) | <.001 | ||
| Small for gestational age infants | 3.9 (3.0-5.0) | 1.5 (1.2-1.8) | <.001 | ||
The P value for the likelihood ratio (LR) test is for a comparison between the HbSS and HbSC group results.