Characteristics of studies comparing pregnancy outcome in women with HbSS against women with no SCD
| . | Country . | GNI per capita $ (year) . | Duration of study . | HbSS women, N (N pregnancies) . | No. SCD women, N (N pregnancies) . | Transfusion details . | Quality of reporting (NOS) of 9 . |
|---|---|---|---|---|---|---|---|
| Total N | 1276 (1523) | 2848 (3183) | |||||
| First author and year of publication | |||||||
| Afolabi 200912 | Nigeria | 2450 (2012) | 1996-2000 | 75 (75) | 150 (150) | 40% HbSS transfused (on clinical indications) vs 1.9% controls | 6 |
| Al Jama 200913 | Saudi Arabia | 30 160 (2011) | 2000-2007 | 145 (255) | 500 (500) | 34% HbSS transfused (on clinical indications) vs 5.6% controls | 7 |
| Al Kahtani 201214 | Saudi Arabia | 30 160 (2011) | 2001-2010 | 392 (392) | 784 (784) | Top-up transfusion: 33.7% HbSS; exchange transfusion: 3.6% HbSS (on clinical indications) | 7 |
| Balgir 199715 | India | 3910 (2012) | 1991-1992 | 51 (146) | 73 (251) | No data on transfusion for study population | 4 |
| Daigavane 2013*16 | India | 3910 (2012) | 2010-2012 | 60 (60) | 100 (100) | 46.6% HbSS (on clinical indications) vs 3.3% controls | 4 |
| Howard 199517 | United Kingdom | 37 340 (2012) | 1991-1993 | 39 (39) | 100 (100) | 56.4% HbSS transfused in 1st or 2nd trimester (prophylactic) | 4 |
| Ngo 201018 | France | 36 720 (2012) | 1994-2004 | 95 (95) | 128 (128) | Prophylactic transfusion for all HbSS | 7 |
| Serjeant 2004*19 | Jamaica | 5120 (2012) | 1973-2004 | 52 (94) | 68 (157) | 17.3% HbSS transfused (on clinical indications) vs 5.8% controls | 7 |
| Sun 200120 | United States | 52 610 (2012) | 1980-1995 | 69 (69) | 61 (129) | 59% of HbSS transfused (on clinical indications) vs 0% controls | 6 |
| Thame 2013*21 | Jamaica | 5120 (2012) | 2005-2008 | 41 (41) | 41 (41) | No data on transfusion for study population | 6 |
| Thame 200722 | Jamaica | 5120 (2012) | 1992-2002 | 126 (126) | 126 (126) | No data on transfusion for study population | 7 |
| Wilson 201223 | Ghana | 1910 (2012) | 2007-2008 | 131 (131) | 717 (717) | No data on transfusion for study population | 5 |
| . | Country . | GNI per capita $ (year) . | Duration of study . | HbSS women, N (N pregnancies) . | No. SCD women, N (N pregnancies) . | Transfusion details . | Quality of reporting (NOS) of 9 . |
|---|---|---|---|---|---|---|---|
| Total N | 1276 (1523) | 2848 (3183) | |||||
| First author and year of publication | |||||||
| Afolabi 200912 | Nigeria | 2450 (2012) | 1996-2000 | 75 (75) | 150 (150) | 40% HbSS transfused (on clinical indications) vs 1.9% controls | 6 |
| Al Jama 200913 | Saudi Arabia | 30 160 (2011) | 2000-2007 | 145 (255) | 500 (500) | 34% HbSS transfused (on clinical indications) vs 5.6% controls | 7 |
| Al Kahtani 201214 | Saudi Arabia | 30 160 (2011) | 2001-2010 | 392 (392) | 784 (784) | Top-up transfusion: 33.7% HbSS; exchange transfusion: 3.6% HbSS (on clinical indications) | 7 |
| Balgir 199715 | India | 3910 (2012) | 1991-1992 | 51 (146) | 73 (251) | No data on transfusion for study population | 4 |
| Daigavane 2013*16 | India | 3910 (2012) | 2010-2012 | 60 (60) | 100 (100) | 46.6% HbSS (on clinical indications) vs 3.3% controls | 4 |
| Howard 199517 | United Kingdom | 37 340 (2012) | 1991-1993 | 39 (39) | 100 (100) | 56.4% HbSS transfused in 1st or 2nd trimester (prophylactic) | 4 |
| Ngo 201018 | France | 36 720 (2012) | 1994-2004 | 95 (95) | 128 (128) | Prophylactic transfusion for all HbSS | 7 |
| Serjeant 2004*19 | Jamaica | 5120 (2012) | 1973-2004 | 52 (94) | 68 (157) | 17.3% HbSS transfused (on clinical indications) vs 5.8% controls | 7 |
| Sun 200120 | United States | 52 610 (2012) | 1980-1995 | 69 (69) | 61 (129) | 59% of HbSS transfused (on clinical indications) vs 0% controls | 6 |
| Thame 2013*21 | Jamaica | 5120 (2012) | 2005-2008 | 41 (41) | 41 (41) | No data on transfusion for study population | 6 |
| Thame 200722 | Jamaica | 5120 (2012) | 1992-2002 | 126 (126) | 126 (126) | No data on transfusion for study population | 7 |
| Wilson 201223 | Ghana | 1910 (2012) | 2007-2008 | 131 (131) | 717 (717) | No data on transfusion for study population | 5 |
All studies were historical cohort of pregnancy studies except for those marked with an asterisk, which were prospective pregnancy cohort studies.